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解剖可行性研究是否能比传统的转化研究更快地推动神经外科手术并使患者受益?

Can anatomical feasibility studies drive neurosurgical procedures and reach patients faster than traditional translational research?

机构信息

Department of Neurosurgery, Tulane Center for Clinical Neurosciences, Tulane University School of Medicine, 131 S. Robertson St. Suite 1300, New Orleans, LA, 70112, USA.

Department of Structural & Cellular Biology, Tulane University School of Medicine, New Orleans, LA, USA.

出版信息

Neurosurg Rev. 2022 Feb;45(1):891-896. doi: 10.1007/s10143-021-01626-x. Epub 2021 Aug 19.

DOI:10.1007/s10143-021-01626-x
PMID:34409576
Abstract

Often, surgical techniques are practiced and studied in the anatomy laboratory. Occasionally, new surgical methods are developed with cadaveric anatomical studies. Some cadaveric feasibility studies, if published, might go on to be used by surgeons from around the world for improved patient care. Herein, we review our experience with 37 published anatomical feasibility studies over an 18-year period (2002-2020) and analyze the literature for published examples of surgical application of these same anatomical studies. We found that, for cadaveric anatomical feasibility studies within 7 years of their publication date, approximately 22% will be used in neurosurgery with the clinical applications published. Of these studies awarded clinical citation within 7 years of publication, the median time to that citation was approximately 3.4 years. As the average time for translational research to reach patient care is 17 years, cadaveric anatomical studies in this series reached patient care much sooner than traditional translational research. Cadaveric anatomical studies, based on our experience, can drive neurosurgical procedures.

摘要

通常,外科技术在解剖实验室中进行实践和研究。偶尔,新的外科方法也会通过对尸体的解剖研究来开发。一些尸体解剖可行性研究,如果发表,可能会被世界各地的外科医生用于提高患者护理水平。在此,我们回顾了我们在 18 年期间(2002-2020 年)进行的 37 项已发表的解剖可行性研究的经验,并分析了文献中这些相同解剖研究的外科应用的发表案例。我们发现,对于发表后 7 年内的尸体解剖可行性研究,大约有 22%将用于神经外科,其临床应用已经发表。在发表后 7 年内获得临床引用的这些研究中,获得引用的中位数时间约为 3.4 年。由于转化研究达到患者护理的平均时间为 17 年,因此本系列中的尸体解剖研究比传统转化研究更早地应用于患者护理。根据我们的经验,尸体解剖研究可以推动神经外科手术。

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