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腹膜外肾移植:体重≤15kg 和>15kg 的儿童之间的比较。单机构经验。

Extraperitoneal kidney transplantation: a comparison between children weighting ≤15 kg and >15 kg. Experience of a single institution.

机构信息

Pediatric Urology, Department of Women's and Children's Health, University of Padua, Padua, Italy.

Pediatric Surgery, Department of Women's and Children's Health, University of Padua, Padua, Italy.

出版信息

Transpl Int. 2021 Nov;34(11):2394-2402. doi: 10.1111/tri.14015. Epub 2021 Sep 22.

DOI:10.1111/tri.14015
PMID:34411366
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9292289/
Abstract

Extraperitoneal approach is sometimes recommended for kidney transplantation (KT) in children weighting <15 kg. We hypothesized that this approach might be as successful as in patients with normal weight. Data of all consecutive KTs performed between 2013 and 2019 were retrospectively reviewed. Early outcomes and surgical complications were compared between children weighing ≤15 kg (low-weight (LW) group) and those weighing >15 kg (Normal-weight (NW) group). All the 108 KTs were performed through an extraperitoneal approach. The LW group included 31 patients (mean age 3.5 ± 1.4 years), whose mean weight was 11.1 ± 2.0 kg. In the LW group,-a primary graft nonfunction (PNGF) occurred in one patient (3.2%), surgical complications occurred in nine (29%), with four venous thrombosis. In the NW group, PNGF occurred in one case (1.3%), delayed graft function (DGF) in eight (10%), surgical complications in 11 (14%) with only one case of venous thrombosis. In both groups, no need for patch during wound closure and no wound dehiscence were reported. The extraperitoneal approach can be effectively used in LW children. No differences were observed in the overall complication rate (P = 0.10), except for the occurrence of venous thrombosis (P = 0.02). This might be related to patients' characteristics of the LW group.

摘要

经腹腔途径有时被推荐用于体重<15kg 的儿童肾移植(KT)。我们假设这种方法与体重正常的患者一样成功。回顾性分析了 2013 年至 2019 年期间连续进行的所有 KT 数据。比较了体重≤15kg(低体重(LW)组)和体重>15kg(正常体重(NW)组)患儿的早期结果和手术并发症。所有 108 例 KT 均通过经腹腔途径进行。LW 组包括 31 例患者(平均年龄 3.5±1.4 岁),平均体重为 11.1±2.0kg。在 LW 组中,1 例患者(3.2%)发生原发性移植物无功能(PNGF),9 例(29%)发生手术并发症,其中 4 例发生静脉血栓形成。在 NW 组中,1 例(1.3%)发生 PNGF,8 例(10%)发生延迟移植物功能(DGF),11 例(14%)发生手术并发症,仅 1 例发生静脉血栓形成。在两组中,均未报告在伤口闭合时需要补片和伤口裂开。经腹腔途径可有效应用于 LW 患儿。除静脉血栓形成发生率(P=0.02)外,两组总体并发症发生率(P=0.10)无差异。这可能与 LW 组患者的特点有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81dc/9292289/ec9b5809eec2/TRI-34-2394-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81dc/9292289/ec9b5809eec2/TRI-34-2394-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81dc/9292289/ec9b5809eec2/TRI-34-2394-g002.jpg

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Renal allograft loss due to renal vascular thrombosis in the US pediatric renal transplantation.美国儿科肾移植中因肾血管血栓形成导致的肾移植丧失。
Pediatr Nephrol. 2019 Sep;34(9):1545-1555. doi: 10.1007/s00467-019-04264-0. Epub 2019 May 26.
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Transplantation of adult-size kidneys in small pediatric recipients: A single-center experience.
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Pediatr Transplant. 2019 Jun;23(4):e13401. doi: 10.1111/petr.13401. Epub 2019 Mar 27.
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