Keating P J, Black J F, Watson D W
Br J Anaesth. 1978 Dec;50(12):1247-50. doi: 10.1093/bja/50.12.1247.
Glycopyrrolate or cimetidine was administered before operation to patients undergoing elective surgery. After the induction of anaesthesia, the stomach contents were retrieved and the volume and pH measured. Neither drug diminished the volume of gastric contents compared with control. Glycopyrrolate produced little diminution in hydrogen ion concentration. Cimetidine caused a marked increase in pH with a mean [h+] 3.2 x 10(-3) g litre-1 compared with 1.4 x 10(-2) g litre-1 in the controls and 1.1 x 10(-2) g litre-1 in the glycopyrrolate group. Seventy-seven per cent of the patients receiving cimetidine had a pH greater than 2.5.
在择期手术患者术前给予格隆溴铵或西咪替丁。麻醉诱导后，抽取胃内容物并测量其容量和pH值。与对照组相比，两种药物均未减少胃内容物的容量。格隆溴铵对氢离子浓度的降低作用很小。西咪替丁使pH值显著升高，平均[H⁺]为3.2×10⁻³克/升，而对照组为1.4×10⁻²克/升，格隆溴铵组为1.1×10⁻²克/升。接受西咪替丁治疗的患者中有77%的pH值大于2.5。
