Wang Jinjiao, Cato Kenrick, Conwell Yeates, Yu Fang, Heffner Kathi, Caprio Thomas V, Nathan Kobi, Monroe Todd B, Muench Ulrike, Li Yue
Elaine Hubbard Center for Nursing Research on Aging, School of Nursing, University of Rochester, Rochester, New York, USA.
Columbia University School of Nursing, New York, New York, USA.
J Am Geriatr Soc. 2021 Dec;69(12):3545-3556. doi: 10.1111/jgs.17420. Epub 2021 Aug 21.
Pain management is important to post-acute functional recovery, yet older persons with Alzheimer's disease and related dementias (ADRD) are often undertreated for pain. The main objectives were (1) to examine the relationship between ADRD and analgesic use among Medicare home health care (HHC) recipients with daily interfering pain, and (2) to examine the impact of analgesic use on functional outcome in patients with and without ADRD.
We analyzed longitudinal data from the Outcome and Assessment Information Set, Medicare HHC claims, and HHC electronic medical records during a 60-day HHC episode. The sample included 6048 Medicare beneficiaries ≥65 years receiving care from an HHC agency in New York in 2019 who reported daily interfering pain. Analgesic use was assessed during HHC medication reconciliation and included any analgesic, non-opioid analgesic, and opioid. ADRD was identified from ICD-10 codes (HHC claims) and cognitive impairment symptoms (Outcome and Assessment Information Set [OASIS]). Functional outcome was measured as change in the composite Activity of Daily Living (ADL) limitation score in the HHC episode.
ADRD was related to a lower likelihood of using any analgesic (odds ratio [OR] = 0.66, 95% confidence interval [CI]: 0.49, 0.90, p = 0.008) and opioids (OR = 0.54, 95% CI: 0.47, 0.62, p < 0.001), but not related to non-opioid analgesic use (OR = 0.94, 95% CI: 0.74, 1.18, p = 0.58). Stratified analyses showed that any analgesic use (β = -0.43, 95% CI: -0.73, -0.13, p = 0.004) and non-opioid analgesic use (β = -0.31, 95% CI: -0.56, -0.06, p = 0.016) were associated with greater ADL improvement in patients with ADRD, but not in patients without ADRD. Opioid use was not significantly related to ADL improvement regardless of ADRD status.
HHC patients with ADRD may be undertreated for pain, yet pain treatment is essential for functional improvement in HHC. HHC clinicians and policymakers should ensure adequate pain management for older persons with ADRD for improved functional outcomes.
疼痛管理对急性后期功能恢复很重要,但患有阿尔茨海默病及相关痴呆症(ADRD)的老年人疼痛治疗往往不足。主要目标是:(1)研究患有日常干扰性疼痛的医疗保险家庭健康护理(HHC)接受者中ADRD与镇痛药使用之间的关系;(2)研究镇痛药使用对有无ADRD患者功能结局的影响。
我们分析了在60天的HHC期间,来自结局与评估信息集、医疗保险HHC索赔以及HHC电子病历的纵向数据。样本包括2019年在纽约从HHC机构接受护理且报告有日常干扰性疼痛的6048名年龄≥65岁的医疗保险受益人。在HHC药物核对期间评估镇痛药使用情况,包括任何镇痛药、非阿片类镇痛药和阿片类药物。通过国际疾病分类第十版编码(HHC索赔)和认知障碍症状(结局与评估信息集[OASIS])确定ADRD。功能结局以HHC期间日常生活活动(ADL)综合受限评分的变化来衡量。
ADRD与使用任何镇痛药(比值比[OR]=0.66,95%置信区间[CI]:0.49,0.90,p=0.008)和阿片类药物(OR=0.54,95%CI:0.47,0.62,p<0.001)的可能性较低相关,但与非阿片类镇痛药使用无关(OR=0.94,95%CI:0.74,1.18,p=0.58)。分层分析显示,任何镇痛药使用(β=-0.43,95%CI:-0.73,-0.13,p=0.004)和非阿片类镇痛药使用(β=-0.31,95%CI:-0.56,-0.06,p=0.016)与ADRD患者ADL改善程度更大相关,但与无ADRD患者无关。无论ADRD状态如何,阿片类药物使用与ADL改善均无显著相关性。
患有ADRD的HHC患者疼痛治疗可能不足,但疼痛治疗对HHC患者的功能改善至关重要。HHC临床医生和政策制定者应确保为患有ADRD的老年人进行充分的疼痛管理,以改善功能结局。