Murad Vanessa, Kim E Edmund
Department of Nuclear Medicine, Seoul National University Hospital, 101, Daehak-ro Jongno-gu, Seoul, 03080 South Korea.
Department of Diagnostic Imaging, Fundacion Santa Fe de Bogota University Hospital, Bogota, Colombia.
Nucl Med Mol Imaging. 2021 Aug;55(4):186-193. doi: 10.1007/s13139-021-00705-7. Epub 2021 Jun 22.
The World Health Organization classification divides thymomas according to morphology, epithelial component, and cell atypia. They are grouped into 3 large subgroups: low-risk thymomas (types A, AB, and B1), high-risk thymomas (types B2 and B3), and thymic carcinomas. Tumor subtype represents an independent prognostic factor, which determines therapeutic decision. All thymomas show some degree of F-FDG uptake, which tends to increase with the grade of malignancy; this is related to glucose transporter 1 (GLUT1) expression. This review collects all types of thymomas with illustrative images and provides a guide to get familiar with histological characteristics of the lesions and have them in mind because, even imaging findings can overlap among subtypes, certain characteristics can be combined to make an accurate diagnosis based on F-FDG PET-CT findings.
世界卫生组织的分类根据形态学、上皮成分和细胞异型性对胸腺瘤进行划分。它们被分为3个大的亚组：低风险胸腺瘤（A、AB和B1型）、高风险胸腺瘤（B2和B3型）以及胸腺癌。肿瘤亚型是一个独立的预后因素，决定着治疗决策。所有胸腺瘤都表现出一定程度的F-FDG摄取，且摄取量往往随着恶性程度的增加而升高；这与葡萄糖转运蛋白1（GLUT1）的表达有关。本综述收集了各类胸腺瘤并配有说明性图像，旨在提供一个指南，以便熟悉这些病变的组织学特征并牢记于心，因为尽管各亚型之间的影像学表现可能会有重叠，但某些特征可以结合起来，基于F-FDG PET-CT检查结果做出准确诊断。
