Department of Pathology, Fattouma Bourguiba University Hospital, Monastir, Tunisia.
Department of Neurosurgery, Fattouma Bourguiba University Hospital, Monastir, Tunisia.
Pan Afr Med J. 2021 May 26;39:78. doi: 10.11604/pamj.2021.39.78.26043. eCollection 2021.
Human papillomavirus (HPV)-related multiphenotypic sinonasal carcinoma (HMSC), is a new entity that is restricted to the sinonasal tract and is associated with high-risk HPV. This tumor is suggested to have an indolent behavior with a better prognosis than other carcinomas. We report a unique case of HMSC with a locally aggressive behavior. It is about a 61-year-old men presented with 12 months of unilateral progressive olfactory dysfunction accompanied by exophthalmia of the left eye, declining vision and headaches for 6 months. Computed tomography imaging revealed a voluminous mass occupying the ethmoid, maxillary and frontal sinus with bony destruction of the left ethmoidal blade. Histology showed a tumor composed of variably sized nests, separated by thick mucoid stroma. Tumor cells are plasmacytoid with hyperchromatic nuclei and frequent mitoses. Immunohistochemistry revealed that these cells were positive for cytokeratin AE1/AE3, p16 and negative for CK7, CK20, CD117, p40, p63, S100, synaptophysin and chromogranin.
人乳头瘤病毒（HPV）相关多表型鼻鼻窦癌（HMSC）是一种新的实体，仅限于鼻鼻窦道，与高危 HPV 相关。与其他癌相比，这种肿瘤具有惰性行为，预后较好。我们报告了一例具有局部侵袭性行为的 HMSC 独特病例。这是一名 61 岁男性，表现为单侧进行性嗅觉功能障碍 12 个月，伴左眼突出、视力下降和头痛 6 个月。计算机断层扫描成像显示大量肿块占据筛窦、上颌窦和额窦，左侧筛骨叶片有骨破坏。组织学显示肿瘤由大小不一的巢组成，由厚的粘蛋白基质分隔。肿瘤细胞呈浆细胞样，核深染，有频繁的有丝分裂。免疫组织化学显示这些细胞对细胞角蛋白 AE1/AE3、p16 呈阳性，对 CK7、CK20、CD117、p40、p63、S100、突触素和嗜铬粒蛋白呈阴性。
