Nik-Azis Nik-Madihah, Mohd Nurulhuda, Baharin Badiah, Said Mohd Shahrir Mohamed, Fadzilah Fazalina Mohd, Haflah Nor Hazla Mohamed
Dr., BDS, DClindent, Department of Restorative Dentistry, Faculty of Dentistry, Universiti Kebangsaaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.
Dr., DDS, MClinDent, Department of Restorative Dentistry, Faculty of Dentistry, University Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.
Germs. 2021 Jun 2;11(2):266-286. doi: 10.18683/germs.2021.1263. eCollection 2021 Jun.
The link between periodontal disease (PD) and rheumatoid arthritis (RA) has been hypothesized to lie in the anti-cyclic citrullinated protein antibody (ACPA) molecules present in seropositive RA. This review aimed to discuss how RA and specifically ACPA-positive RA link to PD, and appraise the epidemiological evidence on the relationship between ACPA-positive RA and PD. Articles were searched following the PRISMA guideline across the MEDLINE, Web of Science, Scopus and Cochrane Library databases. A total of 21 articles met the inclusion criteria of reporting the epidemiological data on the different ACPA status of the subjects with RA and PD (or periodontitis) parameters. A discrepancy is noted in the epidemiological evidence on the difference in the prevalence and severity of PD between ACPA-positive and ACPA-negative RA patients. Although the link between RA and PD is mostly discussed in terms of ACPA, reports on the different manifestations of PD between the two RA subsets remains inconclusive.
牙周病（PD）与类风湿性关节炎（RA）之间的联系被认为与血清阳性RA中存在的抗环瓜氨酸化蛋白抗体（ACPA）分子有关。本综述旨在探讨RA，特别是ACPA阳性RA与PD之间的联系，并评估ACPA阳性RA与PD之间关系的流行病学证据。按照PRISMA指南在MEDLINE、科学网、Scopus和Cochrane图书馆数据库中检索文章。共有21篇文章符合纳入标准，报告了RA患者不同ACPA状态以及PD（或牙周炎）参数的流行病学数据。ACPA阳性和ACPA阴性RA患者在PD患病率和严重程度差异方面的流行病学证据存在差异。尽管RA与PD之间的联系大多围绕ACPA进行讨论，但关于两个RA亚组中PD不同表现的报告尚无定论。
