Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California, San Diego, La Jolla, California, USA.
Department of Ophthalmology, Inje University Sanggye Paik Hospital, Seoul, South Korea.
Br J Ophthalmol. 2023 Feb;107(2):207-214. doi: 10.1136/bjophthalmol-2021-319574. Epub 2021 Aug 23.
BACKGROUND/AIMS: To investigate the relationship between the foveal avascular zone (FAZ) parameters assessed by optical coherence tomography angiography (OCTA) and central visual field parameters in glaucoma and healthy subjects.
One hundred and eighty-eight subjects (248 eyes), including 24 healthy (38 eyes), 37 glaucoma suspect (42 eyes, and 127 primary open angle glaucoma (POAG) patients (168 eyes), underwent imaging using OCTA and standard automated perimetry using the 24-2 and 10-2 Swedish Interactive Thresholding Algorithm. OCTA-based and OCT-based FAZ parameters (superficial FAZ area, FAZ circumference), foveal vessel density (FD300) and foveal thickness were measured. The correlation between FAZ parameters and visual field parameters was assessed using linear mixed model.
Axial length adjusted-FAZ area was not different among the three groups (mean (95% CI)): in healthy 0.31 (0.27 to 0.36) mm, glaucoma suspect 0.29 (0.26 to 0.31) mm and POAG eyes 0.28 (0.27 to 0.30) mm (p=0.578). FD300 was lower in glaucoma suspect 49.1% (47.9% to 50.4%) and POAG eyes 48.7% (48.1% to 49.4%) than healthy eyes 50.5% (49.3% to 51.7%) though the difference was not statistically significant (p=0.071). Lower FD300 was associated with worse 24-2 and 10-2 visual field mean deviation and foveal threshold in multivariable linear mixed models (all p<0.05). In addition, a smaller FAZ area was associated with lower intraocular pressure (IOP) (p=0.026).
The FD300, but not the FAZ area was correlated with 10° central visual field mean deviation and foveal threshold in healthy, glaucoma suspect and POAG eyes. In contrast, a smaller FAZ area was associated with lower IOP.
背景/目的：研究光学相干断层扫描血管造影（OCTA）评估的中心凹无血管区（FAZ）参数与青光眼和健康受试者中心视力参数之间的关系。
对 188 名受试者（248 只眼）进行成像，包括 24 名健康受试者（38 只眼）、37 名青光眼疑似患者（42 只眼）和 127 名原发性开角型青光眼（POAG）患者（168 只眼），采用 OCTA 和标准自动视野计（使用 24-2 和 10-2 瑞典交互阈值算法）。测量基于 OCTA 和基于 OCT 的 FAZ 参数（浅层 FAZ 面积、FAZ 周长）、中心凹血管密度（FD300）和中心凹厚度。使用线性混合模型评估 FAZ 参数与视野参数之间的相关性。
在三组（平均值（95%CI））中，轴向长度校正后的 FAZ 区域没有差异：健康组 0.31（0.27 至 0.36）mm，青光眼疑似组 0.29（0.26 至 0.31）mm 和 POAG 眼 0.28（0.27 至 0.30）mm（p=0.578）。与健康眼 50.5%（49.3%至 51.7%）相比，青光眼疑似患者 49.1%（47.9%至 50.4%）和 POAG 眼 48.7%（48.1%至 49.4%）的 FD300 较低，尽管差异无统计学意义（p=0.071）。多变量线性混合模型显示，较低的 FD300 与 24-2 和 10-2 视野平均偏差和中心凹阈值较差相关（均 p<0.05）。此外，较小的 FAZ 区域与较低的眼内压（IOP）相关（p=0.026）。
在健康、青光眼疑似和 POAG 眼中，FD300 而不是 FAZ 区域与 10°中心视野平均偏差和中心凹阈值相关。相比之下，较小的 FAZ 区域与较低的 IOP 相关。
