Center on Aging, University of Connecticut Health Center, Farmington, CT, USA.
Australian Institute for Musculoskeletal Science (AIMSS), The University of Melbourne and Western Health, St Albans, VIC 3021, Australia; Department of Medicine-Western Health, Melbourne Medical School, The University of Melbourne, St Albans, VIC 3021, Australia.
Exp Gerontol. 2021 Oct 15;154:111521. doi: 10.1016/j.exger.2021.111521. Epub 2021 Aug 21.
Old age is associated with declines in bone density and muscle mass and function, which predisposes to mobility disability, falls, and fractures. Poor nutritional status, a risk factor for several age-related pathologies, becomes prevalent in old age and contributes to the structural and functional changes of the musculoskeletal system that increases the risk of osteoporosis, sarcopenia, osteosarcopenia, and physical frailty. The biological mechanisms underpinning these pathologies often overlap and include loss of proteostasis, impaired redox functioning, and chronic low-grade inflammation. Thus, provision of nutrients with anabolic/anticatabolic, antioxidant, and anti-inflammatory properties may be an effective strategy to offset these age-related pathologies. We searched PUBMED for pre-clinical and clinical work examining the effects of nutrients with a combined effect on muscle and bone. This review summarizes recent evidence on the mechanisms of action and potential clinical use of nutrients that concomitantly improve muscle and bone health in older persons.
衰老与骨密度和肌肉质量及功能的下降有关，这会导致行动障碍、跌倒和骨折。营养状况不良是多种与年龄相关的病理的一个风险因素，在老年时更为普遍，导致骨骼肌肉系统的结构和功能发生变化，增加了骨质疏松症、肌肉减少症、骨肌减少症和身体虚弱的风险。这些病理的潜在生物学机制经常重叠，包括蛋白质稳态丧失、氧化还原功能受损和慢性低度炎症。因此，提供具有合成代谢/抗分解代谢、抗氧化和抗炎特性的营养素可能是抵消这些与年龄相关的病理的有效策略。我们在 PUBMED 上搜索了研究营养素对肌肉和骨骼综合影响的临床前和临床工作。本综述总结了最近关于同时改善老年人肌肉和骨骼健康的营养素的作用机制和潜在临床应用的证据。
