College of Nursing, University of Saskatchewan, Health Sciences Building, E-Wing, Room 4248, 104 Clinic Place, SK, S7N 2Z4, Saskatoon, Canada.
Department of Psychiatry, University of Saskatchewan, Ellis Hall, RUH, Room 112, SK, S7N 0W8, Saskatoon, Canada.
BMC Pregnancy Childbirth. 2021 Aug 25;21(1):583. doi: 10.1186/s12884-021-04021-y.
Antenatal women experience an increased level of mood and anxiety symptoms, which have negative effects on mothers' mental and physical health as well as the health of their newborns. The relation of maternal depression and anxiety in pregnancy with neonate outcomes is well-studied with inconsistent findings. However, the association between antenatal mood instability (MI) and neonatal outcomes has not been investigated even though antenatal women experience an elevated level of MI. We sought to address this gap and to contribute to the literature about pregnancy neonate outcomes by examining the relationship among antenatal MI, depression, and anxiety and neonatal outcomes.
A prospective cohort of women (n = 555) participated in this study at early pregnancy (T1, 17.4 ± 4.9 weeks) and late pregnancy (T2, 30.6 ± 2.7 weeks). The Edinburgh Postnatal Depression Scale (EPDS) was used to assess antenatal depressive symptoms, anxiety was measured by the EPDS anxiety subscale, and mood instability was measured by a visual analogue scale with five questions. These mood states together with stress, social support, as well as lifestyle were also examined in relation to neonatal outcomes using chi-square tests and logistic regression models.
Mood instability, depression, and anxiety were unrelated to adverse neonatal outcomes. Only primiparous status was associated with small for gestational age after Bonferroni correction.
We report no associations between antenatal mood symptoms including MI, depression, and anxiety and neonatal outcomes. More studies are required to further explore the relationship between antenatal mood instability, depression, and anxiety and neonatal outcomes.
产前妇女会经历更高水平的情绪和焦虑症状，这对母亲的身心健康以及新生儿的健康都有负面影响。母亲在怀孕期间的抑郁和焦虑与新生儿结局的关系已经得到了充分的研究，但产前情绪不稳定（MI）与新生儿结局之间的关系尚未得到调查，尽管产前妇女经历了更高水平的 MI。我们试图解决这一差距，并通过研究产前 MI、抑郁和焦虑与新生儿结局之间的关系，为妊娠新生儿结局的文献做出贡献。
一项前瞻性队列研究纳入了 555 名妇女（n=555），她们在早期妊娠（T1，17.4±4.9 周）和晚期妊娠（T2，30.6±2.7 周）时参与了这项研究。使用爱丁堡产后抑郁量表（EPDS）评估产前抑郁症状，使用 EPDS 焦虑分量表评估焦虑，使用 5 个问题的视觉模拟量表评估情绪不稳定。使用卡方检验和逻辑回归模型，还检查了这些情绪状态与压力、社会支持以及生活方式与新生儿结局的关系。
情绪不稳定、抑郁和焦虑与不良新生儿结局无关。只有初产妇状态与经 Bonferroni 校正后的小于胎龄儿有关。
我们报告产前情绪症状（包括 MI、抑郁和焦虑）与新生儿结局之间没有关联。需要更多的研究来进一步探索产前情绪不稳定、抑郁和焦虑与新生儿结局之间的关系。
