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口腔后部和口咽癌的联合治疗。

Combined treatment of cancer of the posterior oral cavity and oropharynx.

作者信息

Geoffray B, Luboinski B, Wibault P, Micheau C, Richard J M

机构信息

Department of Head and Neck Surgery, Institut Gustave Roussy, Villejuif, France.

出版信息

Clin Otolaryngol Allied Sci. 1987 Dec;12(6):429-39. doi: 10.1111/j.1365-2273.1987.tb00229.x.

Abstract

Ninety composite resections were carried out as primary treatment for a squamous carcinoma of the tonsillar region between 1970 and 1978. All patients have been followed-up for at least 3 years, except for 5 who have been lost to follow-up. All patients received postoperative radiotherapy (between 50 Gy and 65 Gy depending on the tumour resection status). Sixty-one patients received preoperative chemotherapy and 42% had clinical reduction of tumour size. The overall survival was 45.5% at 3 years and 43% at 5 years. Local recurrences were the most frequent oncological failure (25%). Tumours classed T3, insufficient tumour resection and lymph node invasion had poor prognostic value. We emphasize the necessity for primary surgery with preoperative chemotherapy and postoperative radiotherapy for squamous carcinoma of the posterior oral cavity and oropharynx.

摘要

1970年至1978年间,对90例扁桃体区鳞状细胞癌患者进行了联合切除术作为主要治疗手段。除5例失访患者外,所有患者均接受了至少3年的随访。所有患者均接受了术后放疗(根据肿瘤切除情况,放疗剂量在50 Gy至65 Gy之间)。61例患者接受了术前化疗,42%的患者肿瘤大小出现临床缩小。3年总生存率为45.5%,5年总生存率为43%。局部复发是最常见的肿瘤学失败情况(25%)。T3期肿瘤、肿瘤切除不充分和淋巴结侵犯具有不良预后价值。我们强调对于口腔后部和口咽鳞状细胞癌,进行术前化疗和术后放疗的一期手术的必要性。

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