Falcomer C, Vertuani G, Boggian M, Scatturin A, Spisani S, Cavalletti T, Traniello S
Department of Pharmaceutical Sciences, University of Ferrara, Italy.
Farmaco Sci. 1987 Nov;42(11):815-22.
The tetrapeptides CHO-Met-Leu-Phe-CO-NH-(CH2)n-COOMe (n = 1-5) have been synthesized. These peptides containing an omega-amino acid residue in position 4 exhibit a very high chemotactic activity. Like the chemotactic peptide CHO-Met-Leu-Phe-OMe, these tetrapeptides in solution undoubtedly adopt an "active" conformation which allows a strong interaction with the receptor on the human polymorphonuclear leukocyte surface.
已合成四肽CHO-Met-Leu-Phe-CO-NH-(CH2)n-COOMe（n = 1-5）。这些在第4位含有ω-氨基酸残基的肽表现出非常高的趋化活性。与趋化肽CHO-Met-Leu-Phe-OMe一样，这些溶液中的四肽无疑采用了一种“活性”构象，这种构象允许与人类多形核白细胞表面的受体发生强烈相互作用。
