Shivananda S, Hordijk M L, Peña A S, Mayberry J F
National Institute of Public Health and Environmental Hygiene, Bilthoven, The Netherlands.
Digestion. 1987;38(3):187-92. doi: 10.1159/000199589.
Demographic data obtained from epidemiological studies of Crohn's disease and ulcerative proctocolitis in Regio Leiden (Leiden health care region) were compared. Ulcerative colitis (6.8 cases/10(5) population/year) had an incidence almost twice that of Crohn's disease (3.9/10(5)/year; p less than 0.001). Each disease occurred with equal frequency in both sexes and diagnosis of the diseases occurred at similar ages (Spearman's correlation coefficient = 0.84; p less than 0.01). Where ulcerative colitis was common in the various municipalities so was Crohn's disease (Spearman's correlation coefficient = 0.88; p less than 0.001). No cases of Crohn's disease were identified amongst migrants, but 6 cases of ulcerative colitis (prevalence = 85/10(5); 95% confidence interval = 35-195) were found. This difference was significance (p less than 0.05). It seems likely that the two diseases may simply represent the opposite ends of a continuous spectrum of inflammatory bowel disease.
对从莱顿地区（莱顿医疗保健区）克罗恩病和溃疡性直肠结肠炎的流行病学研究中获取的人口统计学数据进行了比较。溃疡性结肠炎（6.8例/10⁵人口/年）的发病率几乎是克罗恩病（3.9/10⁵/年；p<0.001）的两倍。两种疾病在男女中的发病频率相同，且发病年龄相似（斯皮尔曼相关系数=0.84；p<0.01）。在各个市镇中溃疡性结肠炎常见的地方，克罗恩病也常见（斯皮尔曼相关系数=0.88；p<0.001）。在移民中未发现克罗恩病病例，但发现了6例溃疡性结肠炎（患病率=85/10⁵；95%置信区间=35-195）。这种差异具有统计学意义（p<0.05）。这两种疾病似乎可能只是炎症性肠病连续谱的两端。
