Birmingham VA Medical Center, Birmingham, AL 35294; Department of Medicine at School of Medicine; Division of Epidemiology at School of Public Health, University of Alabama at Birmingham, Birmingham, AL 35294-0022.
Minneapolis VAHCS, Minneapolis, MN; Department of Medicine, University of Minnesota, Minneapolis, MN 55121.
J Clin Epidemiol. 2021 Dec;140:13-21. doi: 10.1016/j.jclinepi.2021.08.023. Epub 2021 Aug 22.
To assess whether change in HRQOL over a seven-year period was associated with subsequent mortality and hospitalization, after adjusting for important covariates, in a cohort of U.S. Veterans.
We used data from a cohort of Veterans who completed a HRQOL survey in 1998 (Short-Form 36 for Veterans [SF-36V]) and a 2006 follow-up (SF-12V) HRQOL survey and SF12V scores were calculated at both time-points. We used logistic regression analyses to model the relationship between changes in the SF12-V physical component (PCS) and mental health component (MCS) scores and 1-year hospitalization and 1-year and 3.3-year mortality after the 2006 follow-up survey.
13,900 participants provided data for both the initial and follow-up surveys. We found no significant associations between changes in PCS or MCS and one-year hospitalization after adjusting for follow-up HRQOL and other covariates. We found significant but relatively weak associations between changes in MCS and our mortality outcomes.
Given the follow-up MCS and PCS, change in PCS over the previous 7 years added little information for predicting mortality and hospitalization Although the change in MCS added some information for predicting mortality. Therefore, knowledge of patient's current HRQOL generally provides meaningful information for predicting subsequent mortality and hospitalization.
在调整重要协变量后,评估美国退伍军人队列中,7 年内健康相关生活质量(HRQOL)变化与随后的死亡率和住院率之间的关系。
我们使用了一个退伍军人队列的数据,该队列在 1998 年完成了一次 HRQOL 调查(退伍军人短式 36 项健康调查 [SF-36V]),并在 2006 年进行了后续(SF-12V)HRQOL 调查,并且在两个时间点都计算了 SF12V 评分。我们使用逻辑回归分析来模拟 SF12-V 生理成分(PCS)和心理健康成分(MCS)评分变化与 2006 年随访调查后 1 年住院和 1 年及 3.3 年死亡率之间的关系。
13900 名参与者同时提供了初始和随访调查的数据。我们发现,在调整了随访 HRQOL 和其他协变量后,PCS 或 MCS 的变化与一年住院率之间没有显著关联。我们发现 MCS 的变化与我们的死亡率结果之间存在显著但相对较弱的关联。
考虑到随访时的 MCS 和 PCS,过去 7 年中 PCS 的变化对预测死亡率和住院率几乎没有提供额外信息。虽然 MCS 的变化对预测死亡率提供了一些信息,但增加的信息量相对较小。因此,了解患者当前的 HRQOL 通常为预测随后的死亡率和住院率提供了有意义的信息。