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一名患有急性肝脓肿的中年健康男性的菌血症:病例报告及1970年至2020年文献综述

Bacteremia in a Middle-Aged Healthy Man with Acute Hepatic Abscess: Case Report and Literature Review, 1970-2020.

作者信息

Wang Jiazheng, Guo Rui, Ma Wanshan, Dong Xiutao, Yan Shaofeng, Xie Wenyan

机构信息

Department of Clinical Laboratory Medicine, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Medicine and Health Key Laboratory of Laboratory Medicine, Jinan, People's Republic of China.

Department of Neurosurgery, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Medicine and Health Key Laboratory of Neurosurgery, Jinan, People's Republic of China.

出版信息

Infect Drug Resist. 2021 Aug 19;14:3307-3318. doi: 10.2147/IDR.S321282. eCollection 2021.

Abstract

() is a rare but significant human emerging pathogen. Infections caused by it are rare and little-known, both on clinical and therapeutical aspects, in spite of new emergence of bacteria isolation and identification techniques. In this article, we report a case involving a previously healthy 52-year-old man suffering from a newly diagnosed hepatic abscess who developed bacteremia, which was treated successfully using empirical therapy with ertapenem and teicoplanin. To the best of our knowledge, this is the first documented report of bacteremia related specifically to liver abscess. Cases related to this bacterial species are infrequent and sporadic; thus, we reviewed English literature on infection in PubMed/MEDLINE in the last 50 years. A total of 31 sporadic cases were identified. The majority of patients were male (71%), had an average age of 54.3 years and presented predisposing conditions, such as digestive system trouble (45.2%), immunocompromised state (25.8%) or risk factors (22.6%). Two of the cases had more than one predisposing factors. Fever was common (93.5%). Average days to diagnosis of them were 6.8 days. MALDI-TOF MS is emerging as a fast and useful tool in the identification of it. Teicoplanin, vancomycin, amoxicillin-clavulanate, metronidazole, clindamycin, cefoxitin, chloramphenicol, and carbapenems appear to be the most used antibiotic treatment options. The purpose of this review is to increase awareness about the clinical infections caused by .

摘要

()是一种罕见但重要的人类新出现病原体。尽管细菌分离和鉴定技术不断涌现,但由它引起的感染在临床和治疗方面都很罕见且鲜为人知。在本文中,我们报告了一例病例,一名52岁既往健康的男性新诊断为肝脓肿并发生了菌血症,使用厄他培南和替考拉宁经验性治疗成功治愈。据我们所知,这是第一例有记录的与肝脓肿相关的菌血症报告。与该细菌物种相关的病例并不常见且呈散发性;因此,我们回顾了过去50年PubMed/MEDLINE上关于该感染的英文文献。共确定了31例散发病例。大多数患者为男性(71%),平均年龄54.3岁,存在易感因素,如消化系统疾病(45.2%)、免疫功能低下状态(25.8%)或危险因素(22.6%)。其中两例有不止一种易感因素。发热很常见(93.5%)。他们平均诊断天数为6.8天。基质辅助激光解吸电离飞行时间质谱(MALDI-TOF MS)正在成为鉴定它的一种快速且有用的工具。替考拉宁、万古霉素、阿莫西林-克拉维酸、甲硝唑、克林霉素、头孢西丁、氯霉素和碳青霉烯类似乎是最常用的抗生素治疗选择。本综述的目的是提高对由()引起临床感染的认识。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76ca/8382309/2319280e3fd2/IDR-14-3307-g0001.jpg

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