采用气相色谱-质谱联用技术测定人尿中甲基泼尼松龙代谢物
Determination of methylprednisolone metabolites in human urine by gas chromatography-mass spectrometry.
作者信息
Rodchenkov G M, Uralets V P, Semenov V A
机构信息
Anti-Doping Centre, Central Institute of Sports Medicine, Moscow, U.S.S.R.
出版信息
J Chromatogr. 1987 Dec 25;423:15-22. doi: 10.1016/0378-4347(87)80323-7.
Methylprednisolone and its metabolites were studied as their methoxyamine-trimethylsilyl derivatives by means of capillary gas chromatography-mass spectrometry. The expected unchanged drug and 11-keto and 20-hydroxy metabolites were found in human urine. The typical metabolites are 6,7-dehydro analogues of the above-mentioned compounds. Characteristic gas chromatographic profiles of urine steroids were obtained. Retention indices and m/z values are presented for methylprednisolone and its main metabolites.
通过毛细管气相色谱 - 质谱联用技术，对甲基泼尼松龙及其代谢产物的甲氧胺 - 三甲基硅烷基衍生物进行了研究。在人尿液中发现了预期的未变化药物以及11 - 酮和20 - 羟基代谢产物。典型的代谢产物是上述化合物的6,7 - 脱氢类似物。获得了尿甾体的特征性气相色谱图。给出了甲基泼尼松龙及其主要代谢产物的保留指数和m/z值。
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