Axelsson K F, Litsne H, Lorentzon M
Närhälsan Norrmalm Health Centre, Skövde, Sweden.
Sahlgrenska Osteoporosis Centre, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, Mölndal, Building K, 6th Floor, 431 80, Mölndal, Sweden.
Osteoporos Int. 2022 Jan;33(1):47-56. doi: 10.1007/s00198-021-06068-1. Epub 2021 Aug 26.
In this retrospective cohort study of 6604 adults, 65 years or older, admitted with seasonal influenza at Swedish hospitals, and 330,200 age- and sex-matched controls from the general population admitted for other reasons, were included. Patients with influenza had increased risk of fall injuries and fractures compared to controls.
Fractures and fall injuries often lead to disability, increased morbidity, and mortality. Older adults are at higher risk of influenza-related complications such as pneumonia, cardiovascular events, and deaths, but the risk of fractures and fall injuries is unclear. The primary objective of this study was to investigate the risk of fractures and fall injuries in older patients after admission with seasonal influenza.
In this retrospective cohort study of 6604 adults, 65 years or older, admitted with seasonal influenza at Swedish hospitals (from December 1, 2015, to December 31, 2017) and 330,200 age- and sex-matched controls from the general population and admitted for other reasons, the risk of fracture or fall injury was investigated.
The mean (SD) age of the 6604 influenza patients was 80.9 (8.1) years and 50.1% were women. During the first year after hospital discharge, there were 680 (10.3%) patients suffering from a fracture or fall injury among the patients with influenza, and 25,807 (7.8%) among the controls, corresponding to incident rates of 141 (95% CI, 131-152) and 111 (95% CI, 110-112) fractures or fall injuries per 1000 person-years respectively, translating to a significantly increased risk of fracture or fall injury in a Cox regression model (hazard ratio (HR) 1.28 (95% CI, 1.19-1.38)), a risk that was maintained after multivariable adjustment (HR 1.22 (95% CI 1.13-1.31)).
Older adults admitted with influenza diagnosis have an increased risk of fracture or fall injury during the first year after discharge.
在这项对6604名65岁及以上因季节性流感入住瑞典医院的成年人进行的回顾性队列研究中，纳入了330200名来自普通人群、因其他原因入院且年龄和性别匹配的对照者。与对照者相比，流感患者发生跌倒损伤和骨折的风险增加。
骨折和跌倒损伤常导致残疾、发病率增加和死亡率上升。老年人患流感相关并发症（如肺炎、心血管事件和死亡）的风险较高，但骨折和跌倒损伤的风险尚不清楚。本研究的主要目的是调查老年患者因季节性流感入院后发生骨折和跌倒损伤的风险。
在这项对6604名65岁及以上因季节性流感入住瑞典医院（2015年12月1日至2017年12月31日）的成年人以及330200名来自普通人群、因其他原因入院且年龄和性别匹配的对照者进行的回顾性队列研究中，调查了骨折或跌倒损伤的风险。
6604名流感患者的平均（标准差）年龄为80.9（8.1）岁，50.1%为女性。出院后的第一年，流感患者中有680名（10.3%）发生骨折或跌倒损伤，对照者中有25807名（7.8%），骨折或跌倒损伤的发生率分别为每1000人年141例（95%置信区间，131 - 152）和111例（95%置信区间，110 - 112），在Cox回归模型中，这意味着骨折或跌倒损伤的风险显著增加（风险比（HR）1.28（95%置信区间，1.19 - 1.38）），多变量调整后该风险仍然存在（HR 1.22（95%置信区间1.13 - 1.31））。
被诊断为流感的老年人在出院后的第一年发生骨折或跌倒损伤的风险增加。
