Finsterer Josef
Klinik Landstrasse, Messerli Institute, Postfach 20, 1180, Vienna, Austria.
Metab Brain Dis. 2021 Oct;36(7):1697-1698. doi: 10.1007/s11011-021-00831-3. Epub 2021 Aug 26.
Stroke-like episodes (SLEs) are a common phenotypic feature of various syndromic and non-syndromic mitochondrial disorders (MIDs), particularly of mitochondrial encephalopathy, lactic acidosis, and stroke-like episode syndrome (MELAS). The morphological equivalent of a SLE is the stroke-like lesion (SLE), a dynamic lesion, which initially expands to regress after weeks or months. SLLs present with typical morphological and structural abnormalities on multimodal magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS), and FDG-PET. It is crucial to clearly delineate SLLs from ischemic stroke, as treatment and outcome vary significantly between the two.
类中风发作（SLEs）是各种综合征性和非综合征性线粒体疾病（MIDs）的常见表型特征，尤其是线粒体脑肌病伴乳酸血症和类中风发作综合征（MELAS）。SLE的形态学对应物是类中风样病变（SLL），这是一种动态病变，最初会扩大，数周或数月后会消退。SLL在多模态磁共振成像（MRI）、磁共振波谱（MRS）和氟代脱氧葡萄糖正电子发射断层显像（FDG-PET）上呈现典型的形态和结构异常。明确区分SLL和缺血性中风至关重要，因为两者的治疗方法和预后差异很大。
