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一种用于体外光动力疗法的基于经编发光织物的装置：描述、表征及其在人癌细胞系上的应用。

A Warp-Knitted Light-Emitting Fabric-Based Device for In Vitro Photodynamic Therapy: Description, Characterization, and Application on Human Cancer Cell Lines.

作者信息

Thécua Elise, Ziane Laurine, Grolez Guillaume Paul, Fagart Alexandre, Kumar Abhishek, Leroux Bertrand, Baert Gregory, Deleporte Pascal, Vermandel Maximilien, Vignion-Dewalle Anne-Sophie, Delhem Nadira, Mordon Serge

机构信息

U1189-ONCO-THAI-Laser Assisted Therapy and Immunotherapies for Oncology, CHU Lille, Inserm, Univ. Lille, F-59000 Lille, France.

MDB TEXINOV, F-38110 Saint-Didier de la Tour, France.

出版信息

Cancers (Basel). 2021 Aug 15;13(16):4109. doi: 10.3390/cancers13164109.

DOI:10.3390/cancers13164109
PMID:34439263
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8394325/
Abstract

Photodynamic therapy (PDT) appears to be a promising strategy in biomedical applications. However, the complexity of its parameters prevents wide acceptance. This work presents and characterizes a novel optical device based on knitted light-emitting fabrics and dedicated to in vitro PDT involving low irradiance over a long illumination period. Technical characterization of this device, called CELL-LEF, is performed. A cytotoxic study of 5-ALA-mediated PDT on human cancer cell lines is provided as a proof of concept. The target of delivering an irradiance of 1 mW/cm over 750 cm is achieved (mean: 0.99 mW/cm; standard deviation: 0.13 mW/cm). The device can maintain a stable temperature with the mean thermal distribution of 35.1 °C (min: 30.7 °C; max: 38.4 °C). In vitro outcomes show that 5-ALA PDT using CELL-LEF consistently and effectively induced a decrease in tumor cell viability: Almost all the HepG2 cells died after 80 min of illumination, while less than 60% of U87 cell viability remained. CELL-LEF is suitable for in vitro PDT involving low irradiance over a long illumination period.

摘要

光动力疗法（PDT）在生物医学应用中似乎是一种很有前景的策略。然而，其参数的复杂性阻碍了它的广泛应用。这项工作展示并描述了一种基于针织发光织物的新型光学设备，该设备专门用于体外光动力疗法，在长时间照射过程中具有低辐照度。对这种名为CELL-LEF的设备进行了技术特性表征。提供了一项关于5-氨基乙酰丙酸介导的光动力疗法对人类癌细胞系的细胞毒性研究，作为概念验证。实现了在750平方厘米面积上提供1毫瓦/平方厘米辐照度的目标（平均值：0.99毫瓦/平方厘米；标准差：0.13毫瓦/平方厘米）。该设备能够保持稳定的温度，平均热分布为35.1℃（最小值：30.7℃；最大值：38.4℃）。体外实验结果表明，使用CELL-LEF的5-氨基乙酰丙酸光动力疗法持续有效地降低了肿瘤细胞活力：几乎所有的HepG2细胞在照射80分钟后死亡，而U87细胞的活力仅剩余不到60%。CELL-LEF适用于长时间低辐照度的体外光动力疗法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7dc/8394325/69541a749dac/cancers-13-04109-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7dc/8394325/91d13d3b64ef/cancers-13-04109-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7dc/8394325/91c121b79e70/cancers-13-04109-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7dc/8394325/0c049c5f18a3/cancers-13-04109-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7dc/8394325/423bdebc0330/cancers-13-04109-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7dc/8394325/589c83ee1448/cancers-13-04109-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7dc/8394325/92ef96b1ef3a/cancers-13-04109-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7dc/8394325/2e29dfbaa95c/cancers-13-04109-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7dc/8394325/6e668764156e/cancers-13-04109-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7dc/8394325/238742f91974/cancers-13-04109-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7dc/8394325/2ace1fcf7130/cancers-13-04109-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7dc/8394325/69541a749dac/cancers-13-04109-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7dc/8394325/91d13d3b64ef/cancers-13-04109-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7dc/8394325/91c121b79e70/cancers-13-04109-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7dc/8394325/0c049c5f18a3/cancers-13-04109-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7dc/8394325/423bdebc0330/cancers-13-04109-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7dc/8394325/589c83ee1448/cancers-13-04109-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7dc/8394325/92ef96b1ef3a/cancers-13-04109-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7dc/8394325/2e29dfbaa95c/cancers-13-04109-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7dc/8394325/6e668764156e/cancers-13-04109-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7dc/8394325/238742f91974/cancers-13-04109-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7dc/8394325/2ace1fcf7130/cancers-13-04109-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7dc/8394325/69541a749dac/cancers-13-04109-g011.jpg

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