Golińska Paulina Beata, Sawicki Artur Józef, Bieleninik Łucja, Bidzan Mariola
Institute of Psychology, University of Gdańsk, 80-309 Gdańsk, Poland.
Brain Sci. 2021 Jul 30;11(8):1013. doi: 10.3390/brainsci11081013.
(1) Background: This study compared anterior attentional-intentional system performance between three groups: Parkinson's disease (PD) patients with normal cognition (PD-NC), with mild cognitive impairment (PD-MCI), and a comparison group (CG). It also evaluated the feasibility of the recruitment and study procedures; (2) Methods: From 45 participants recruited, 39 were allocated (mean age 65.31; 43.59% men) to PD-NC, PD-MCI and CG (13 per group). To assess attention, we used three tasks from the ROtman-Baycrest Battery for Investigating Attention: Simple Reaction time (RT), Choice RT, and Prepare RT. We conducted a mixed-model analysis of variance with a 3 (groups) × 4 (tasks) design to compare reaction times; (3) Results: PD-MCI had slower reaction times than PD-NC ( = 0.028) and the CG ( = 0.052); there was no difference between PD-NC and CG. PD-MCI might perform worse on monitoring tasks than PD-NC, = -1.68, = 0.092. Nearly half the volunteers from the CG and 87% of all eligible patients were enrolled in the study and completed all neuropsychological procedures; (4) Conclusions: General cognitive decline appears related to partial deficits in energization and tends to impair attentional monitoring. Furthermore, PD-NC exhibited similar reaction times to the CG. Results from the feasibility study contributed to the definitive study.
(1) 背景：本研究比较了三组人群的前注意-意向系统表现：认知正常的帕金森病（PD）患者（PD-NC）、轻度认知障碍的PD患者（PD-MCI）以及对照组（CG）。它还评估了招募和研究程序的可行性；(2) 方法：从招募的45名参与者中，39人（平均年龄65.31岁；43.59%为男性）被分配到PD-NC组、PD-MCI组和CG组（每组13人）。为评估注意力，我们使用了罗特曼-贝克莱注意力调查电池中的三项任务：简单反应时（RT）、选择反应时和准备反应时。我们采用3（组）×4（任务）设计的混合模型方差分析来比较反应时间；(3) 结果：PD-MCI组的反应时间比PD-NC组（P = 0.028）和CG组（P = 0.052）慢；PD-NC组和CG组之间没有差异。PD-MCI组在监测任务上的表现可能比PD-NC组差，t = -1.68，P = 0.092。CG组近一半的志愿者和所有符合条件患者的87%参与了该研究并完成了所有神经心理学程序；(4) 结论：一般认知衰退似乎与精力充沛方面的部分缺陷有关，并往往会损害注意力监测。此外，PD-NC组的反应时间与CG组相似。可行性研究的结果为确定性研究提供了帮助。
