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单核细胞活化、炎症及微生物易位标志物与酒精使用障碍中的肝纤维化相关。

Markers of Monocyte Activation, Inflammation, and Microbial Translocation Are Associated with Liver Fibrosis in Alcohol Use Disorder.

作者信息

Fuster Daniel, Garcia-Calvo Xavier, Farré Oriol, Zuluaga Paola, Bolao Ferran, Leis Alba, Hernández-Rubio Anna, Rivas Inmaculada, Muga Robert

机构信息

Addiction Unit, Department of Internal Medicine, Hospital Universitari Germans Trias i Pujol, 08916 Badalona, Barcelona, Spain.

Department of Medicine, Universitat Autònoma de Barcelona, 08916 Badalona, Barcelona, Spain.

出版信息

J Clin Med. 2021 Aug 8;10(16):3496. doi: 10.3390/jcm10163496.

Abstract

BACKGROUND

The association between markers of inflammation (interleukin (IL)-6 and IL-10), monocyte activation (sCD163 and sCD14), and microbial translocation (lipopolysaccharide (LPS) and LPS binding protein) and liver fibrosis in patients with alcohol use disorder (AUD) and no overt liver disease is not well established.

METHODS

We studied patients admitted for treatment of AUD at two hospitals in Barcelona. Advanced liver fibrosis (ALF) was defined as FIB-4 > 3.25.

RESULTS

A total of 353 participants (76.3% male) were included and 94 (26.5%) had ALF. In adjusted correlation analyses, sCD163, sCD14, IL-6, IL-10, and LPS binding protein levels directly correlated with FIB-4 values (adjusted correlation coefficients 0.214, 0.452, 0.317, 0.204, and 0.171, respectively). However, LPS levels were inversely associated with FIB-4 (-0.283). All plasma marker levels in the highest quartile, except LPS, were associated with ALF (sCD163, sCD14, IL-6, IL-10, and LPS binding protein: adjusted odds ratio (aOR) 11.49 (95% confidence interval 6.42-20.56), 1.87 (1.11-3.16), 2.99 (1.79-5.01), 1.84 (1.11-3.16), and 2.13 (1.30-3.50), respectively). Conversely, LPS levels in the lowest quartile were associated with ALF (aOR 2.58 (1.48-4.58), < 0.01).

CONCLUSION

In AUD patients, plasma levels of the markers of inflammation, monocyte activation, and microbial translocation are associated with ALF.

摘要

背景

炎症标志物(白细胞介素(IL)-6和IL-10)、单核细胞活化(可溶性CD163和可溶性CD14)以及微生物易位(脂多糖(LPS)和LPS结合蛋白)与酒精使用障碍(AUD)且无明显肝脏疾病患者的肝纤维化之间的关联尚未明确。

方法

我们研究了巴塞罗那两家医院收治的AUD患者。进展性肝纤维化(ALF)定义为FIB-4>3.25。

结果

共纳入353名参与者(76.3%为男性),其中94名(26.5%)患有ALF。在调整后的相关性分析中,可溶性CD163、可溶性CD14、IL-6、IL-10和LPS结合蛋白水平与FIB-4值直接相关(调整后的相关系数分别为0.214、0.452、0.317、0.204和0.171)。然而,LPS水平与FIB-4呈负相关(-0.283)。除LPS外,最高四分位数的所有血浆标志物水平均与ALF相关(可溶性CD163、可溶性CD14、IL-6、IL-10和LPS结合蛋白:调整后的比值比(aOR)分别为11.49(95%置信区间6.42-20.56)、1.87(1.11-3.16)、2.99(1.79-5.01)、1.84(1.11-3.16)和2.13(1.30-3.50))。相反,最低四分位数的LPS水平与ALF相关(aOR 2.58(1.48-4.58),P<0.01)。

结论

在AUD患者中,炎症、单核细胞活化和微生物易位标志物的血浆水平与ALF相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44f8/8396829/39f379afcce7/jcm-10-03496-g001.jpg

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