Xu Du-Chang, Luo Yu-Xiao, Xu Yuan-Qing
School of Life Science, Beijing Institute of Technology, Beijing 100081, China.
University Medical Center Göttingen, University of Göttingen, 37075 Göttingen, Germany.
Micromachines (Basel). 2021 Aug 13;12(8):957. doi: 10.3390/mi12080957.
As an indicator of health risk, the deposition of microparticles in terminal pulmonary acini is of great significance in the medical field. To control particulate pollution and optimize aerosol delivery, it is necessary to perform an in-depth study of the microparticle deposition in terminal pulmonary acini; however, little research has been done on this topic. This paper proposes a respiratory movement model of terminal pulmonary acini using an immersed boundary-lattice Boltzmann method. In addition, we explored the effect of gravity direction, respiratory rate, microparticle diameter, and other parameters on the microparticles deposition process and distribution, under the airflow in the acinar wall. It was found that the deposition of microparticles is sensitive to gravity direction, and the growth of the respiratory rate increases the rate of microparticle migration and deposition. It was observed that the gravity effect is enhanced by increasing the diameter of microparticles, causing a high deposition and dispersion rate. The study reveals the dynamic correlation between the respiration process and the movement of microparticles, which is of reference value to figure out the pathogenicity mechanism of inhalable particles and to optimize the aerosol delivery.
作为健康风险的一个指标，微粒在终末肺腺泡中的沉积在医学领域具有重要意义。为了控制颗粒污染并优化气溶胶输送，有必要对终末肺腺泡中的微粒沉积进行深入研究；然而，关于这个主题的研究很少。本文采用浸入边界-格子玻尔兹曼方法提出了终末肺腺泡的呼吸运动模型。此外，我们探讨了重力方向、呼吸频率、微粒直径等参数在腺泡壁气流作用下对微粒沉积过程和分布的影响。研究发现，微粒沉积对重力方向敏感，呼吸频率的增加会提高微粒迁移和沉积的速率。观察到通过增加微粒直径可增强重力效应，导致高沉积和分散速率。该研究揭示了呼吸过程与微粒运动之间的动态相关性，对于弄清楚可吸入颗粒的致病机制以及优化气溶胶输送具有参考价值。
