非H-2抗原可在正常细胞成年受体中诱导高移植物抗宿主病死亡率。
Non-H-2 antigens can induce high GVH mortality in adult recipients of normal cells.
作者信息
Halle-Pannenko O, Pritchard L L, Motta R, Mathé G
出版信息
Biomedicine. 1978 Nov;29(7):253-5.
PMID:34444
Abstract
It is demonstrated that, under experimental conditions resembling those used for bone marrow grafting in man, disparity for minor histocompatibility antigens alone (i.e., antigens coded for by genes not included in the major histocompatibility complex) is in fact sufficient for the induction of severe lethal graft-versus-host disease in adult (DBA/2 X B10.D2)F1 recipients of normal B10.D2 myeloid and lymphoid cells.
摘要
结果表明，在类似于人类骨髓移植所采用的实验条件下，仅次要组织相容性抗原（即由主要组织相容性复合体以外的基因编码的抗原）的差异，实际上就足以在正常B10.D2骨髓细胞和淋巴细胞的成年（DBA/2×B10.D2）F1受体中诱发严重的致死性移植物抗宿主病。
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