Bastyr University Research Institute, Kenmore, WA 98028, USA.
Department of Naturopathic Medicine, Bastyr University, Kenmore, WA 98028, USA.
Nutrients. 2021 Aug 16;13(8):2801. doi: 10.3390/nu13082801.
We report the effects of mixed omega-7 fatty acid supplementation on changes in serum hsCRP, TNFα, and IL-6 levels and self-reported outcomes in people with non-specific chronic musculoskeletal discomfort.
A double-blind, placebo-controlled, 1:1 randomized single crossover trial composed of 688 mg/day palmiteolate for the verum and an equivalent amount of medium-chain triglycerides for the placebo.
Data were analyzed in two independent groups and as a crossover group.
From 211 screened participants in 2017-2019, 56 were randomized. Six participants dropped out and fifty completers contributed to the statistical analyses. At baseline, none of the investigated biomarkers were significantly correlated to subjectively assessed musculoskeletal discomfort levels. For the two-group analysis ( = 26 and = 24), none of the serum biomarkers reached statistical significance; however, a statistically significant placebo effect was found in the subjective outcomes.
For the crossover analysis ( = 50), three weeks of supplementation with n7FA containing 688 mg per day of palmiteolate did not reduce serum inflammatory biomarkers nor did it improve subjectively measured quality of life (QoL) compared to placebo. Future studies should explore appropriate biomarkers, sufficient power, length of dosing, inclusion criteria for volunteers with higher BMI, and the verification of palmiteolate versus palmiteolate.
我们报告了混合 ω-7 脂肪酸补充剂对血清 hsCRP、TNFα 和 IL-6 水平变化以及有非特异性慢性肌肉骨骼不适的人群自我报告结果的影响。
一项双盲、安慰剂对照、1:1 随机单交叉试验，包括每天 688 毫克棕榈酸酯的阳性组和等量中链甘油三酯的安慰剂组。
数据在两个独立组和交叉组中进行分析。
在 2017-2019 年筛选的 211 名参与者中，有 56 名被随机分配。6 名参与者退出，50 名完成者参与了统计分析。在基线时，没有任何被调查的生物标志物与主观评估的肌肉骨骼不适水平显著相关。对于两组分析（ = 26 和 = 24），没有任何血清生物标志物具有统计学意义；然而，在主观结果中发现了统计学上显著的安慰剂效应。
对于交叉分析（ = 50），每天补充含 688 毫克棕榈酸酯的 n7FA 三周，与安慰剂相比，既不能降低血清炎症生物标志物，也不能改善主观测量的生活质量（QoL）。未来的研究应该探索适当的生物标志物、足够的效力、给药时间长度、纳入 BMI 较高的志愿者的标准，以及棕榈酸酯与棕榈酸酯的验证。
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