Dallorso S, De Bernardi B, Taccone A, Canale G, Haupt R, Garrè M L
Divisione di Ematologia-Oncologia, Istituto G. Gaslini, Genova, Italia.
Pediatr Med Chir. 1987 Nov-Dec;9(6):735-9.
Ewing's sarcoma (ES) is rarely diagnosed in the pre-school age; these few cases however present a number of difficult diagnostic and therapeutic problems. The Authors describe a series of six such cases aged less than 4 years diagnosed in the period 1974-1987. Standard treatment was modified with the purpose to reduce acute toxicity and late sequelae. These modifications are described in details. Four/6 patients are presently alive disease-free from 29 to 87 months from diagnosis (median, 34 months). Two patients died from acute toxicity. The Authors suggest that young children with ES may be treated successfully with proper adjustments of current protocols. Increased aggressiveness of chemotherapy regimens may compensate for reduced radiotherapy; however, the high susceptibility to infection of youngsters has to be taken into account and makes mandatory a careful monitoring during phases of profound myelodepression.
尤因肉瘤（ES）在学龄前儿童中很少被诊断出来；然而，这少数病例存在一些诊断和治疗上的难题。作者描述了1974年至1987年间诊断出的一系列6例年龄小于4岁的此类病例。为了减少急性毒性和晚期后遗症，对标准治疗方案进行了修改。详细描述了这些修改内容。6例患者中有4例目前存活，自诊断以来无病生存29至87个月（中位数为34个月）。2例患者死于急性毒性反应。作者认为，对当前方案进行适当调整，ES患儿可能会得到成功治疗。化疗方案更强的攻击性可能弥补放疗剂量的减少；然而，必须考虑到幼儿对感染的高易感性，这使得在严重骨髓抑制阶段进行仔细监测成为必要。
