Adhikari Shambhu P, Dev Rubee, Borson Soo
School of Health and Exercise Sciences, University of British Columbia, Kelowna, British Columbia, Canada.
Faculty of Nursing, University of Alberta, Edmonton, Canada.
Int J Alzheimers Dis. 2021 Aug 16;2021:5510093. doi: 10.1155/2021/5510093. eCollection 2021.
The Mini-Cog, a rapid, valid, and reliable screening tool for cognitive impairment, consists of 3-word recall and an executive clock drawing test (CDT). However, CDT requires at least basic literacy and cultural exposure to analog clocks, conditions not met in many population groups around the world. We developed a modification of the Mini-Cog (MMC) for use with nonliterate and literate individuals.
Participants were adults (≥60 years) with no neurological diagnosis, with known cognitive impairment due to stroke, Parkinsonism, traumatic brain injury, or Alzheimer's disease, and whose family members were able to read and write. We replaced the CDT with two tasks of everyday life: a serial subtraction task or a multistep performance task. Family members rated the acceptability and feasibility of the Mini-Cog versions using a 6-point scale and completed a proxy-rated cognitive staging tool, the Dementia Severity Rating Scale (DSRS). Spearman's rho, Mann-Whitney , and chi-square tests were used to evaluate group differences and associations between measures.
Data were collected from 63 participants (75% ≥ 60 years, 67% nonliterate). Literacy was associated with CDT (chi-square strength 0.9, < 0.001). Both MMC versions correlated with DSRS in healthy adults and patients (rho 0.6-0.7, < 0.05). In literate individuals, the acceptability and feasibility of CDT and both alternate distractors were similarly high (5/6).
Two alternate distractor tasks may successfully replace CDT in the Mini-Cog. The MMC versions are promising and deserve further study as screening tools for cognitive impairment in larger and more fully characterized samples.
简易认知筛查量表(Mini-Cog)是一种用于认知障碍的快速、有效且可靠的筛查工具,由3个词语回忆和一项执行功能画钟试验(CDT)组成。然而,画钟试验要求至少具备基本的读写能力以及对模拟时钟的文化认知,而世界上许多人群并不满足这些条件。我们开发了一种简易认知筛查量表的改良版(MMC),用于不识字和识字的个体。
参与者为年龄≥60岁、无神经学诊断、因中风、帕金森病、创伤性脑损伤或阿尔茨海默病导致认知障碍已知且其家庭成员具备读写能力的成年人。我们用两项日常生活任务替代了画钟试验:连续减法任务或多步骤执行任务。家庭成员使用6分制对简易认知筛查量表各版本的可接受性和可行性进行评分,并完成一份代理评定的认知分期工具——痴呆严重程度评定量表(DSRS)。采用斯皮尔曼相关系数、曼-惠特尼检验和卡方检验来评估组间差异以及各项测量指标之间的关联。
收集了63名参与者的数据(75%≥60岁,67%不识字)。读写能力与画钟试验相关(卡方强度0.9,P<0.001)。两个MMC版本在健康成年人和患者中均与DSRS相关(相关系数0.6 - 0.7,P<0.05)。在识字个体中,画钟试验以及两个替代干扰任务的可接受性和可行性同样都很高(5/6)。
两项替代干扰任务可成功替代简易认知筛查量表中的画钟试验。MMC版本很有前景,值得在更大规模且特征更全面的样本中作为认知障碍筛查工具进行进一步研究。