Effect of pressure-controlled ventilation-volume guaranteed mode combined with individualized positive end-expiratory pressure on respiratory mechanics, oxygenation and lung injury in patients undergoing laparoscopic surgery in Trendelenburg position.

The study aimed to investigate the efficacy of PCV-VG combined with individual PEEP during laparoscopic surgery in the Trendelenburg position. 120 patients were randomly divided into four groups: VF group (VCV plus 5cmHO PEEP), PF group (PCV-VG plus 5cmHO PEEP), VI group (VCV plus individual PEEP), and PI group (PCV-VG plus individual PEEP). P, P, Cdyn, PaO/FiO, V/V, A-aDO and Qs/Qt were recorded at T (15 min after the induction of anesthesia), T (60 min after pneumoperitoneum), and T (5 min at the end of anesthesia). The CC16 and IL-6 were measured at T and T. Our results showed that the P was increased in VI and PI group, and the P was lower in PI group at T. At T and T, the Cdyn of PI group was higher than that in other groups, and PaO/FiO was increased in PI group compared with VF and VI group. At T and T, A-aDO of PI and PF group was reduced than that in other groups. The Qs/Qt was decreased in PI group compared with VF and VI group at T and T. At T, V/V in PI group was decreased than other groups. At T, the concentration of CC16 in PI group was lower compared with other groups, and IL-6 level of PI group was decreased than that in VF and VI group. In conclusion, the patients who underwent laparoscopic surgery, PCV-VG combined with individual PEEP produced favorable lung mechanics and oxygenation, and thus reducing inflammatory response and lung injury.Clinical Trial registry: chictr.org. identifier: ChiCTR-2100044928.