Kamil N
Laboratoire d'écotoxicologie, ENVL, INRA, Charbonniéres, France.
Pharmacol Res Commun. 1987 Nov;19(11):767-75. doi: 10.1016/0031-6989(87)90011-7.
Rats (Rattus norvegicus) dosed orally with the rodenticide bromadiolone (0.8 and 3 mg/kg) were sacrificed in groups of 4 rats at various times up to 97 hours after administration. Bromadiolone was assayed in plasma, liver and kidney by an HPLC method. The compound disappeared slowly from the organism with a half-life of 25.7 hours for the 0.8 mg/kg dose and 57.5 hours for the 3 mg/kg. Concentrations in liver were rapidly established and were 14- to 46-fold higher than plasma concentrations. 97 hours after 3 mg/kg dose, liver concentrations were about 1.5 micrograms/g. Bromadiolone levels in kidney were slightly higher than those observed in plasma, with a longer half-life.
给大鼠（褐家鼠）口服杀鼠剂溴敌隆（0.8和3毫克/千克），给药后在长达97小时的不同时间点，以每组4只大鼠的方式进行处死。采用高效液相色谱法测定血浆、肝脏和肾脏中的溴敌隆。该化合物从生物体内缓慢消失，0.8毫克/千克剂量的半衰期为25.7小时，3毫克/千克剂量的半衰期为57.5小时。肝脏中的浓度迅速形成，比血浆浓度高14至46倍。3毫克/千克剂量给药97小时后，肝脏浓度约为1.5微克/克。肾脏中的溴敌隆水平略高于血浆中的水平，半衰期更长。
