Huang Xiaomei, Cui Zefeng, Ding Chenhong, Su Qiuquan, Lin Xuexian, Wang Weili, Yin Qiumiao, Wang Xu
Institute of Quality Standard and Monitoring Technology for Agro-products, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China.
Guangdong Provincial Key Laboratory of Quality & Safety Risk Assessment for Agro-products, Guangzhou 510640, China.
J Agric Food Chem. 2021 Sep 8;69(35):10329-10337. doi: 10.1021/acs.jafc.1c04546. Epub 2021 Aug 27.
Chlorinated paraffins (CPs) are environmental pollutants of emerging concern. Long-chain CPs (LCCPs) are considered of lesser concern than other CPs in food due to their lower accumulation in most organisms. However, LCCPs have been shown to accumulate preferentially in birds. We used ultrahigh-performance liquid chromatography combined with electrospray ionization Orbitrap mass spectrometry (UPLC-ESI-Orbitrap MS) to analyze CPs (CCl) in tissues of free-range hens, their feed, and local soils. Feed was found to be the main source of CP intake. The CP carbon chain length had little impact on their absorption. C-CPs were excreted in preference to C-CPs by laying. The metabolic elimination rates of CPs (0.2 μg/mL) estimated using chicken liver microsomes were in the order CCl (91%) > CCl (57%) > CCl (12%) > CCl (6%). CPs with longer carbon chains accumulated preferentially in muscle and adipose tissues, and the accumulation of specific carbon chain lengths was related to the content and composition of different CPs in the intake source.
氯化石蜡（CPs）是新出现的环境污染物。长链氯化石蜡（LCCPs）在大多数生物体中的积累量较低，因此在食品中被认为比其他氯化石蜡的关注度较低。然而，已表明LCCPs在鸟类中优先积累。我们使用超高效液相色谱结合电喷雾电离轨道阱质谱（UPLC-ESI-Orbitrap MS）分析了散养母鸡组织、其饲料和当地土壤中的氯化石蜡（CCl）。发现饲料是CP摄入的主要来源。CP的碳链长度对其吸收影响很小。通过产蛋，C-CPs比C-CPs更优先排泄。使用鸡肝微粒体估计的CPs（0.2μg/mL）的代谢消除率顺序为CCl（91%）>CCl（57%）>CCl（12%）>CCl（6%）。碳链较长的CPs优先在肌肉和脂肪组织中积累，特定碳链长度的积累与摄入源中不同CPs的含量和组成有关。
