Imad Hisham A, Phadungsombat Juthamas, Nakayama Emi E, Chatapat Lapakorn, Pisutsan Phimphan, Matsee Wasin, Piyaphanee Watcharapong, Nguitragool Wang, Shioda Tatsuo
Mahidol Vivax Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.
Thai Travel Clinic, Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.
Trop Med Infect Dis. 2021 Aug 14;6(3):152. doi: 10.3390/tropicalmed6030152.
Dengue is an overlooked tropical disease for which billions of people are at risk. The disease, caused by a with four distinct serotypes, is transmitted primarily by urban mosquito species. The infection leads to a spectrum of clinical manifestations, with the majority being asymptomatic. Primary dengue fever and, to a greater extent, a subsequent infection with a different serotype is associated with increased severity. Increased global travel and recreational tourism expose individuals naïve to the dengue viruses, the most common arboviral infections among travelers. We describe a cluster of possible primary acute dengue infections in a group of 12 individuals who presented to Bangkok Hospital for Tropical Diseases in 2017. Infection was confirmed by dengue NS1 antigen and multiplex real-time RT-PCR. Nine individuals required hospitalization, and four developed dengue warning signs. Leukocytes, neutrophils, and platelets declined towards defervescence and were negatively correlated with day of illness. Six clinical isolates were identified as dengue serotype-1, with 100% nucleotide identity suggesting that these patients were infected with the same virus.
登革热是一种被忽视的热带疾病，数十亿人面临感染风险。该疾病由一种有四种不同血清型的病毒引起，主要通过城市伊蚊传播。感染会导致一系列临床表现，大多数情况下为无症状感染。初次感染登革热，以及在更大程度上，随后感染不同血清型病毒，都会使病情加重。全球旅行和休闲旅游的增加，使那些未接触过登革病毒的人面临感染风险，登革热是旅行者中最常见的虫媒病毒感染。我们描述了2017年在曼谷热带病医院就诊的12名患者中出现的一组可能的原发性急性登革热感染病例。通过登革热NS1抗原和多重实时逆转录聚合酶链反应（RT-PCR）确诊感染。9人需要住院治疗，4人出现登革热预警信号。白细胞、中性粒细胞和血小板在退热过程中下降，且与患病天数呈负相关。6株临床分离株被鉴定为登革热1型，100%的核苷酸同一性表明这些患者感染的是同一病毒。
