Kulinskiĭ V I, Iashunskiĭ V G
Biull Eksp Biol Med. 1979 Mar;87(3):232-3.
The radioprotective effect (RPE) of some arylalkylamines (AAAs) was studied in experiments on mice. Mesaton and its close analogues were injected subcutaneously 15 minutes prior to irradiation at a dose of 800 rad. The protective effect is exerted by AAAs in low doses (25--50 mumole/kg), the compounds show stable and high RPE (80--80% survival, dose reduction factor being 1.3--1.4) and low toxicity (LD50 = 4--8 mumole/kg). AAAs studied are not less effective than aminothiols. Their pharmacological spectrum--K = LD50/ED50 (200--500) is superior to that of known aminothiols and indolylalkylamines.
在小鼠实验中研究了一些芳基烷基胺（AAA）的辐射防护作用（RPE）。在以800拉德的剂量进行辐照前15分钟，皮下注射美速克新命及其类似物。AAA在低剂量（25 - 50微摩尔/千克）时发挥保护作用，这些化合物显示出稳定且高的RPE（存活率80 - 88%，剂量降低系数为1.3 - 1.4）以及低毒性（半数致死量 = 4 - 8微摩尔/千克）。所研究的AAA的效果不低于氨基硫醇。它们的药理学谱——K = 半数致死量/半数有效量（200 - 500）优于已知的氨基硫醇和吲哚基烷基胺。
