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前列腺腺癌潜在轨迹研究的方法学与概念进展

Methodological and Conceptual Progresses in Studies on the Latent Tracks in PADC.

作者信息

Yamauchi Tomoya, Kanasaki Masato, Barillon Rémi

机构信息

Graduate School of Maritime Sciences, Kobe University, Hyogo 657-8501, Japan.

Institut Pluridisiplinaire Hubert Curien, UMR 7178, CNRS, The University of Strasbourg, 67081 Strasbourg, France.

出版信息

Polymers (Basel). 2021 Aug 10;13(16):2665. doi: 10.3390/polym13162665.

DOI:10.3390/polym13162665
PMID:34451202
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8398540/
Abstract

Modified structure along latent tracks and track formation process have been investigated in poly (allyl diglycol carbonate), PADC, which is well recognized as a sensitive etched track detector. This knowledge is essential to develop novel detectors with improved track registration property. The track structures of protons and heavy ions (He, C, Ne, Ar, Fe, Kr and Xe) have been examined by means of FT-IR spectrometry, covering the stopping power region between 1.2 to 12,000 eV/nm. Through a set of experiments on low- radiations-such as gamma ray-, multi-step damage process by electron hits was confirmed in the radiation-sensitive parts of the PADC repeat-unit. From this result, we unveiled for the first-time the layered structure in tracks, in relation with the number of secondary electrons. We also proved that the etch pit was formed when at least two repeat-units were destroyed along the track radial direction. To evaluate the number of secondary electrons around the tracks, a series of numerical simulations were performed with Geant4-DNA. Therefore, we are proposing new physical criterions to describe the detection thresholds. Furthermore, we propose a present issue of the definition of detection threshold for semi-relativistic C ions. Additionally, as a possible chemical criterion, formation density of hydroxyl group is suggested to express the response of PADC.

摘要

在聚(烯丙基二甘醇碳酸酯)(PADC)中研究了沿潜径迹的改性结构和径迹形成过程,PADC是一种公认的灵敏蚀刻径迹探测器。这些知识对于开发具有改进径迹记录特性的新型探测器至关重要。通过傅里叶变换红外光谱法研究了质子和重离子(He、C、Ne、Ar、Fe、Kr和Xe)的径迹结构,涵盖了1.2至12,000 eV/nm的阻止本领区域。通过一组关于低辐射(如伽马射线)的实验,证实了PADC重复单元的辐射敏感部分中电子撞击导致的多步损伤过程。基于此结果,我们首次揭示了径迹中的层状结构与二次电子数量的关系。我们还证明,当沿径迹径向至少有两个重复单元被破坏时会形成蚀坑。为了评估径迹周围二次电子的数量,使用Geant4-DNA进行了一系列数值模拟。因此,我们提出了描述探测阈值的新物理标准。此外,我们提出了当前半相对论性C离子探测阈值定义的问题。另外,作为一种可能的化学标准,建议用羟基的形成密度来表示PADC的响应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e9d/8398540/5a206c123688/polymers-13-02665-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e9d/8398540/7aba4af39b4b/polymers-13-02665-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e9d/8398540/e8e26dc7574a/polymers-13-02665-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e9d/8398540/f4b735a53fbf/polymers-13-02665-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e9d/8398540/146a467785b8/polymers-13-02665-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e9d/8398540/bcc6f9c5ce55/polymers-13-02665-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e9d/8398540/b539d9281be2/polymers-13-02665-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e9d/8398540/a212e8812c29/polymers-13-02665-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e9d/8398540/a081196825eb/polymers-13-02665-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e9d/8398540/5a206c123688/polymers-13-02665-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e9d/8398540/7aba4af39b4b/polymers-13-02665-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e9d/8398540/e8e26dc7574a/polymers-13-02665-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e9d/8398540/f4b735a53fbf/polymers-13-02665-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e9d/8398540/146a467785b8/polymers-13-02665-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e9d/8398540/bcc6f9c5ce55/polymers-13-02665-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e9d/8398540/b539d9281be2/polymers-13-02665-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e9d/8398540/a212e8812c29/polymers-13-02665-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e9d/8398540/a081196825eb/polymers-13-02665-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e9d/8398540/5a206c123688/polymers-13-02665-g009.jpg

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本文引用的文献

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Investigation of shielding material properties for effective space radiation protection.用于有效空间辐射防护的屏蔽材料特性研究。
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