Burgard Niklas, Kienitz Melanie, Jourdan Claudia, Rüttermann Stefan
Department of Operative Dentistry, Faculty of Dental and Oral Medicine (Carolinum), Goethe-University Frankfurt am Main, 60323 Frankfurt, Germany.
Polymers (Basel). 2021 Aug 21;13(16):2814. doi: 10.3390/polym13162814.
The purpose of the study was to investigate the bacterial viability of the initial biofilm on the surface of experimental modified dental resin composites. Twenty-five healthy individuals with good oral hygiene were included in this study. In a split-mouth design, they received acrylic splints with five experimental composite resin specimens. Four of them were modified with either a novel polymeric hollow-bead delivery system or methacrylated polymerizable Irgasan (Antibacterial B), while one specimen served as an unmodified control (ST). A delivery system based on Poly-Pore was loaded with one of the active agents: Tego Protect 5000 (Antiadhesive A), Dimethicone (Antiadhesive B), or Irgasan (Antibacterial A). All study subjects refrained from toothbrushing during the study period. Specimens were detached from the splints after 8 h and given a live/dead staining before fluorescence microscopy. A Friedman test and a post hoc Nemenyi test were applied with a significance level at < 0.05. In summary, all materials but Antibacterial B showed a significant antibacterial effect compared to ST. The results suggested the role of the materials' chemistry in the dominance of cell adhesion. In conclusion, dental resin composites with Poly-Pore-loaded active agents showed antibacterial effectiveness in situ.
本研究的目的是调查实验性改性牙科树脂复合材料表面初始生物膜的细菌活力。本研究纳入了25名口腔卫生良好的健康个体。采用双侧设计，他们佩戴了带有五个实验性复合树脂标本的丙烯酸夹板。其中四个标本用新型聚合物空心珠递送系统或甲基丙烯酸化可聚合的洗必泰（抗菌剂B）进行了改性，而一个标本作为未改性对照（ST）。基于聚孔的递送系统装载了以下活性剂之一：tego保护5000（抗粘附剂A）、二甲基硅氧烷（抗粘附剂B）或洗必泰（抗菌剂A）。在研究期间，所有研究对象均避免刷牙。8小时后从夹板上取下标本，在荧光显微镜检查前进行活/死染色。应用Friedman检验和事后Nemenyi检验，显著性水平为<0.05。总之，与ST相比，除抗菌剂B外的所有材料均显示出显著的抗菌效果。结果表明材料化学在细胞粘附优势中的作用。总之，负载聚孔活性剂的牙科树脂复合材料在原位显示出抗菌效果。
