de Souza Fernanda Gil, Abrahão Jônatas Santos, Rodrigues Rodrigo Araújo Lima
Laboratório de Vírus, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais 31270-901, Brazil.
Pathogens. 2021 Jul 24;10(8):935. doi: 10.3390/pathogens10080935.
The nucleocytoplasmic large DNA viruses (NCLDV) possess unique characteristics that have drawn the attention of the scientific community, and they are now classified in the phylum . They are characterized by sharing many genes and have their own transcriptional apparatus, which provides certain independence from their host's machinery. Thus, the presence of a robust transcriptional apparatus has raised much discussion about the evolutionary aspects of these viruses and their genomes. Understanding the transcriptional process in NCLDV would provide information regarding their evolutionary history and a better comprehension of the biology of these viruses and their interaction with hosts. In this work, we reviewed NCLDV transcription and performed a comparative functional analysis of the groups of genes expressed at different times of infection of representatives of six different viral families of giant viruses. With this analysis, it was possible to observe a temporal profile of their gene expression and set of genes activated in specific phases throughout the multiplication cycle as a common characteristic of this group. Due to the lack of information regarding the transcriptional regulation process of this group of pathogens, we sought to provide information that contributes to and opens up the field for transcriptional studies of other viruses belonging to .
核质大DNA病毒（NCLDV）具有独特的特征，引起了科学界的关注，它们现在被归类于一个门。它们的特点是共享许多基因，并拥有自己的转录装置，这使其在一定程度上独立于宿主的机制。因此，强大转录装置的存在引发了关于这些病毒及其基因组进化方面的诸多讨论。了解NCLDV中的转录过程将提供有关其进化历史的信息，并有助于更好地理解这些病毒的生物学特性及其与宿主的相互作用。在这项工作中，我们回顾了NCLDV转录，并对六种不同巨型病毒科代表在感染不同时间表达的基因群进行了比较功能分析。通过这种分析，可以观察到它们基因表达的时间概况，以及在整个增殖周期特定阶段激活的基因集，这是该病毒群的一个共同特征。由于缺乏关于这类病原体转录调控过程的信息，我们试图提供有助于并为属于该类的其他病毒转录研究开辟领域的信息。
