东部马脑炎病毒的结构生物学：一种新出现的病毒威胁

The Structural Biology of Eastern Equine Encephalitis Virus, an Emerging Viral Threat.

作者信息

Hasan S Saif, Dey Debajit, Singh Suruchi, Martin Matthew

机构信息

Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 N. Greene Street, Baltimore, MD 21201, USA.

Center for Biomolecular Therapeutics, University of Maryland School of Medicine, 9600 Gudelsky Drive, Rockville, MD 20850, USA.

出版信息

Pathogens. 2021 Jul 31;10(8):973. doi: 10.3390/pathogens10080973.

DOI:10.3390/pathogens10080973

PMID:34451437

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8400090/

Abstract

Alphaviruses are arboviruses that cause arthritis and encephalitis in humans. Eastern Equine Encephalitis Virus (EEEV) is a mosquito-transmitted alphavirus that is implicated in severe encephalitis in humans with high mortality. However, limited insights are available into the fundamental biology of EEEV and residue-level details of its interactions with host proteins. In recent years, outbreaks of EEEV have been reported mainly in the United States, raising concerns about public safety. This review article summarizes recent advances in the structural biology of EEEV based mainly on single-particle cryogenic electron microscopy (cryoEM) structures. Together with functional analyses of EEEV and related alphaviruses, these structural investigations provide clues to how EEEV interacts with host proteins, which may open avenues for the development of therapeutics.

摘要

甲病毒是虫媒病毒，可导致人类患关节炎和脑炎。东部马脑炎病毒（EEEV）是一种通过蚊子传播的甲病毒，与人类严重脑炎有关，死亡率很高。然而，关于EEEV的基础生物学及其与宿主蛋白相互作用的残基水平细节的了解有限。近年来，主要在美国报告了EEEV的爆发，引发了对公共安全的担忧。这篇综述文章主要基于单颗粒低温电子显微镜（cryoEM）结构总结了EEEV结构生物学的最新进展。结合对EEEV和相关甲病毒的功能分析，这些结构研究为EEEV与宿主蛋白的相互作用提供了线索，这可能为治疗方法的开发开辟道路。