Goh Wei Pin, Montoya Sanavia Ana, Ghadiri Mojtaba
Faculty of Engineering and Physical Sciences, University of Leeds, Leeds LS2 9JT, UK.
Pharmaceutics. 2021 Aug 5;13(8):1211. doi: 10.3390/pharmaceutics13081211.
Glidants and lubricants are often used to modify interparticle friction and adhesion in order to improve powder characteristics, such as flowability and compactability. Magnesium stearate (MgSt) powder is widely used as a lubricant. Shear straining causes MgSt particles to break, delaminate, and adhere to the surfaces of the host particles. In this work, a comparison is made of the effect of three mixer types on the lubricating role of MgSt particles. The flow behaviour of α-lactose monohydrate, coated with MgSt at different mass percentages of 0.2, 0.5, 1, and 5 is characterised. The mixing and coating process is carried out by dry blending using Turbula, ProCepT, and Mechanofusion. Measures have been taken to operate under equivalent mixing conditions, as reported in the literature. The flow resistance of the coated samples is measured using the FT4 rheometer. The results indicate that the flow characteristics of the processed powders are remarkably similar in the cases of samples treated by Turbula and Mechanofusion, despite extreme conditions of shear strain rate. The least flow resistance of samples is observed in the case of samples treated by the ProCepT mixer. High-velocity collisions of particles round off the sharp corners and edges, making them less resistant to flow. The optimal percentage of magnesium stearate is found to be approximately 1% by weight for all mixer types, as the addition of higher amounts of lubricant does not further improve the flowability of the material.
助流剂和润滑剂常用于改变颗粒间的摩擦力和附着力，以改善粉末特性，如流动性和可压性。硬脂酸镁（MgSt）粉末被广泛用作润滑剂。剪切应变会导致MgSt颗粒破碎、分层并附着在主体颗粒表面。在这项工作中，比较了三种混合器类型对MgSt颗粒润滑作用的影响。对在0.2%、0.5%、1%和5%不同质量百分比下涂覆有MgSt的一水合α-乳糖的流动行为进行了表征。混合和涂覆过程通过使用Turbula、ProCepT和Mechanofusion进行干混来完成。已采取措施在等效混合条件下操作，如文献报道。使用FT4流变仪测量涂覆样品的流动阻力。结果表明，尽管剪切应变率条件极端，但在Turbula和Mechanofusion处理的样品中，加工后粉末的流动特性非常相似。在ProCepT混合器处理的样品中观察到样品的流动阻力最小。颗粒的高速碰撞使尖角和边缘变圆，使其流动阻力减小。发现所有混合器类型的硬脂酸镁最佳百分比约为1%（重量），因为添加更多量的润滑剂不会进一步改善材料的流动性。
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