服用拉布立林后人体血浆和尿液中氯胍和氯环胍的浓度。
Chlorproguanil and chlorcycloguanil concentrations in human plasma and urine after Lapudrine administration.
作者信息
Edstein M D, Veenendaal J R
机构信息
Army Malaria Research Unit, Military Post Office, Ingleburn, NSW, Australia.
出版信息
Trans R Soc Trop Med Hyg. 1987;81(1):136-9. doi: 10.1016/0035-9203(87)90305-1.
Chlorproguanil and chlorcycloguanil concentrations in human plasma and urine were measured using a high performance liquid chromatographic method. The detection limit in plasma and urine was 5 ng/ml for chlorproguanil and 10 ng/ml for chlorcycloguanil. The elimination half-life of chlorproguanil (Lapudrine) in 2 healthy volunteers, after a single oral dose of the drug, was 14.7 and 16.1 h. No chlorcycloguanil could be detected in plasma over 32 h after dosing.
采用高效液相色谱法测定人血浆和尿液中氯胍和环氯胍的浓度。氯胍在血浆和尿液中的检测限为5 ng/ml，环氯胍为10 ng/ml。2名健康志愿者单次口服氯胍（拉布立林）后，氯胍的消除半衰期分别为14.7小时和16.1小时。给药后32小时内血浆中未检测到环氯胍。
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