冈比亚恶性疟原虫对氯环胍的体外敏感性
In vitro sensitivity of Plasmodium falciparum to chlorcycloguanil in The Gambia.
作者信息
Panton L J, Greenwood B M
出版信息
Trans R Soc Trop Med Hyg. 1985;79(4):491-2. doi: 10.1016/0035-9203(85)90073-2.
PMID:3909555
Abstract
Chlorcycloguanil (10732), the active metabolite of the antifolate chlorproguanil, has been tested in vitro against 17 isolates of Plasmodium falciparum in The Gambia. Minimum inhibitory concentrations were 10(-9) molar or less. 11 isolates simultaneously tested with pyrimethamine were sensitive to 10(-8) molar concentrations of that drug.
摘要
氯环胍（10732）是抗叶酸药物氯胍的活性代谢产物，已在冈比亚针对17株恶性疟原虫进行了体外测试。最低抑菌浓度为10^(-9)摩尔或更低。同时与乙胺嘧啶一起测试的11株菌株对该药物10^(-8)摩尔浓度敏感。
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