Department of Pharmaceutics, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, Henan, PR China; Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, Henan Province, Zhengzhou 450001, Henan, PR China; Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Henan, Zhengzhou 450001, Henan, PR China.
Fudan University Shanghai Cancer Center, and the Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Shanghai Stomatological Hospital, Fudan University, Shanghai 200032, PR China.
Int J Pharm. 2021 Oct 25;608:121051. doi: 10.1016/j.ijpharm.2021.121051. Epub 2021 Aug 25.
The knee joint is one of the largest, most complex, and frequently utilized organs in the body. It is very vulnerable to injuries due to activities, diseases, or accidents, which lead to or cause knee joint injuries in people of all ages. There are several types of knee joint injuries such as contusions, sprains, and strains to the ligament, tendon injuries, cartilage injuries, meniscus injuries, and inflammation of synovial membrane. To date, many drug delivery systems, e.g. nanoparticles, dendrimers, liposomes, micelles, and exosomes, have been used for the treatment of knee joint injuries. They aim to alleviate or reverse the symptoms with an improvement of the function of the knee joint by restoring or curing it. The nanosized structures show good biodegradability, biocompatibility, precise site-specific delivery, prolonged drug release, and enhanced efficacy. They regulate cell proliferation and differentiation, ECM synthesis, proinflammatory factor secretion, etc. to promote repair of injuries. The goal of this review is to outline the finding and studies of the novel strategies of nanotechnology-based drug delivery systems and provide future perspectives to combat the challenges of knee joint injuries by using nanotechnology.
膝关节是人体最大、最复杂、使用最频繁的器官之一。由于活动、疾病或事故，膝关节很容易受伤，导致各年龄段人群的膝关节受伤。膝关节损伤有几种类型，如挫伤、扭伤和韧带拉伤、肌腱损伤、软骨损伤、半月板损伤以及滑膜炎症。迄今为止，已经有许多药物输送系统，如纳米粒子、树枝状聚合物、脂质体、胶束和外泌体，被用于治疗膝关节损伤。它们旨在通过恢复或治愈膝关节来缓解或逆转症状，从而改善膝关节的功能。纳米结构具有良好的生物降解性、生物相容性、精确的靶向输送、延长的药物释放和增强的疗效。它们调节细胞增殖和分化、细胞外基质合成、促炎因子分泌等，以促进损伤修复。本文综述了基于纳米技术的药物输送系统的新策略的研究进展，并提供了未来的展望，以期利用纳米技术应对膝关节损伤的挑战。
