Faculty of Medicine, Ophthalmology Department, Van Yuzuncu Yil University, Turkey.
Faculty of Medicine, Ophthalmology Department, Van Yuzuncu Yil University, Turkey.
Photodiagnosis Photodyn Ther. 2021 Dec;36:102508. doi: 10.1016/j.pdpdt.2021.102508. Epub 2021 Aug 25.
To compare the optical density of iris pigment epithelium (OD) and iris stromal thickness (IST) measurements in patients having pseudoexfoliation syndrome (PXS) and age-gender matched participants.
This is a cross-sectional study. Patients with PXS were enrolled in the study group. Age and gender-matched healthy subjects with no evidence of PXS were recruited as controls. After a comprehensive ophthalmological evaluation, the anterior segment images were acquired using anterior segment spectral-domain optical coherence tomography (AS SD-OCT). The acquired pictures were further analyzed using the ImageJ program. Two investigators measured the OD and the IST of the subjects, and the repeatability and reproducibility were checked. SPSS program was used for statistical analysis.
The PXS group was comprised of twenty-two eyes (n = 22 patients), and the control group contained twenty-six eyes of 26 age and gender-matched healthy subjects. The mean temporal OD of the study group was found to be decreased significantly in comparison to the mean temporal OD of the control eye (p = 0.018). Both the mean nasal (N) and temporal (T) ISTs of the PEX eyes were thinner than the control eyes (p = 0.006 and p = 0.002, respectively). The mean baseline IOP was found to significantly negatively correlate with the OD in the PEX group at both N and T sides (r = -0.531, p = 0.011 and r = -0.685, p < 0.001, respectively).
The pupillary margin IPE was found more depigmented, and the mean N and T IST were significantly thinner in the PEX group by comparison with the age-gender matched healthy controls. The mean baseline IOP was negatively correlated with the pupillary margin's IPE pigmentation degree in patients with PXS.
比较患有假性剥脱综合征（PXS）的患者与年龄和性别相匹配的参与者的虹膜色素上皮（OD）和虹膜基质厚度（IST）的光密度。
这是一项横断面研究。将 PXS 患者纳入研究组。招募年龄和性别相匹配且无 PXS 证据的健康对照者作为对照组。在全面的眼科评估后，使用眼前节谱域光学相干断层扫描（AS SD-OCT）采集眼前节图像。使用 ImageJ 程序进一步分析所获得的图像。两名研究人员测量了受试者的 OD 和 IST，并检查了重复性和可再现性。使用 SPSS 程序进行统计分析。
PXS 组包括 22 只眼（n=22 例患者），对照组包含 26 只眼（26 名年龄和性别相匹配的健康受试者）。与对照组相比，研究组的颞侧 OD 平均值明显降低（p=0.018）。PXS 眼的鼻侧（N）和颞侧（T）IST 平均值均比对照组薄（p=0.006 和 p=0.002）。研究组的平均基线眼压与 PEX 组的 N 和 T 侧 OD 呈显著负相关（r=-0.531，p=0.011 和 r=-0.685，p<0.001）。
与年龄和性别相匹配的健康对照组相比，PXS 患者的瞳孔缘 IPE 色素沉着程度较低，且平均 N 和 T IST 明显较薄。PXS 患者的平均基线眼压与瞳孔缘 IPE 的色素沉着程度呈负相关。
