Luzhnikov E A, Trushin A M, Kabanov O V
Vopr Med Khim. 1987 Nov-Dec;33(6):64-6.
Equilibration patterns of barbiturates adsorption on activated charcoals were studied using aqueous solutions of barbital and sodium barbital and commercially available charcoals BAU, AR-3, AR-B, AR-A, SKT-6A. The rate of barbiturates adsorption was described as an additive function of concentrations of amide, ionized and non-ionized imidol forms calculated considering the reactions of dissociation and hydrolysis. Relatively low equilibrium concentrations of barbiturates in the solid phase and simultaneous sorption of the barbital anion as well as of its non-ionized form were related to the considerable rate of the substance ionization due to both tautomeric transformation and dissociation of the acid formed. The procedure for calculation of equilibrium described assumes that the rate of barbital and sodium barbital adsorption on activated charcoals of various brands might be estimated at various pH values of a solution, based on dissociation and hydrolysis reactions, which is of importance under conditions of the barbiturates enterosorption.
使用巴比妥和巴比妥钠的水溶液以及市售木炭BAU、AR - 3、AR - B、AR - A、SKT - 6A研究了巴比妥类药物在活性炭上的吸附平衡模式。考虑到解离和水解反应，将巴比妥类药物的吸附速率描述为酰胺、离子化和非离子化亚胺醇形式浓度的加和函数。由于互变异构转化和所形成酸的解离，巴比妥类药物在固相中相对较低的平衡浓度以及巴比妥阴离子及其非离子化形式的同时吸附与该物质相当高的电离速率有关。所描述的平衡计算程序假定，基于解离和水解反应，可以在溶液的不同pH值下估算不同品牌活性炭上巴比妥和巴比妥钠的吸附速率，这在巴比妥类药物肠吸附条件下很重要。
