Wang C, Pan Y-C, Jia Z-F, Chi X-M, Wang Y-Q, Yang N, Wu Y-H, Niu J-Q, Jiang J
Department of Hepatology, First Hospital of Jilin University, Changchun, China.
Division of Clinical Research, First Hospital of Jilin University, Changchun, China.
BJOG. 2022 Jan;129(2):241-247. doi: 10.1111/1471-0528.16884. Epub 2021 Sep 21.
To explore the relationships between hepatitis B virus (HBV) DNA, HBV RNA and hepatitis B surface antigen (HBsAg) and to evaluate their predictive value for mother-to-child transmission of HBV.
An observational cohort study.
First Hospital of Jilin University.
HBsAg-positive and hepatitis B e antigen (HBeAg) -positive pregnant women were recruited.
Blood samples were collected from mothers before delivery, and HBV infection of infants was evaluated at 7 months of age.
Overall, 268 mothers and 271 infants were enrolled. HBV DNA and HBsAg levels were correlated (r = 0.699; P < 0.001), and HBV DNA (r = 0.500; P < 0.001) and HBsAg (r = 0.372; P < 0.001) were both correlated with HBV RNA. The areas under the curve for HBV DNA, HBsAg and HBV RNA for prediction of infection were 0.69 (95% CI 0.57-0.82), 0.63 (95% CI 0.51-0.76) and 0.65 (95% CI 0.52-0.78), respectively. Higher HBV DNA (odds ratio [OR] 4.77, 95% CI 1.44-15.86), higher HBsAg (OR 4.13, 95% CI 1.12-15.25) and higher HBV RNA (OR 3.19, 95% CI 1.09-9.32) were risk factors for HBV infection. Analysis of the HBV DNA-RNA-HBsAg Score revealed that it was an independent predictive factor for mother-to-child transmission (the OR of Score 3 was 8.81, 95% CI 2.79-27.82).
HBV DNA, HBV RNA and HBsAg were correlated in HBeAg-positive pregnant women. HBsAg could be considered as a substitute marker of HBV DNA for HBeAg-positive pregnant women in low-income regions. We should pay special attention to pregnant women with high levels of all three markers.
HBsAg could be considered as a substitute marker of HBV DNA for HBeAg-positive pregnant women in low-income regions. Special attention should be given to pregnant women with high levels of all three markers (HBV DNA, HBV RNA and HBsAg).
探讨乙型肝炎病毒（HBV）DNA、HBV RNA与乙型肝炎表面抗原（HBsAg）之间的关系，并评估它们对HBV母婴传播的预测价值。
一项观察性队列研究。
吉林大学第一医院。
招募HBsAg阳性且乙型肝炎e抗原（HBeAg）阳性的孕妇。
在母亲分娩前采集血样，并在婴儿7个月大时评估其HBV感染情况。
共纳入268名母亲和271名婴儿。HBV DNA与HBsAg水平相关（r = 0.699；P < 0.001），HBV DNA（r = 0.500；P < 0.001）和HBsAg（r = 0.372；P < 0.001）均与HBV RNA相关。HBV DNA、HBsAg和HBV RNA预测感染的曲线下面积分别为0.69（95%CI 0.57 - 0.82）、0.63（95%CI 0.51 - 0.76）和0.65（95%CI 0.52 - 0.78）。较高的HBV DNA（优势比[OR] 4.77，95%CI 1.44 - 15.86）、较高的HBsAg（OR 4.13，95%CI 1.12 - 15.25）和较高的HBV RNA（OR 3.19，95%CI 1.09 - 9.32）是HBV感染的危险因素。对HBV DNA - RNA - HBsAg评分的分析表明，它是母婴传播的独立预测因素（评分3的OR为8.81，95%CI 2.79 - 27.82）。
HBeAg阳性孕妇中HBV DNA、HBV RNA和HBsAg相关。在低收入地区，对于HBeAg阳性孕妇，HBsAg可被视为HBV DNA的替代标志物。我们应特别关注三种标志物水平均高的孕妇。
在低收入地区，对于HBeAg阳性孕妇，HBsAg可被视为HBV DNA的替代标志物。应特别关注三种标志物（HBV DNA、HBV RNA和HBsAg）水平均高的孕妇。
