Nuclear Medicine, University of Brescia and ASST Spedali Civili di Brescia, Brescia, Italy.
Nucl Med Commun. 2021 Dec 1;42(12):1293-1300. doi: 10.1097/MNM.0000000000001481.
In the last years, 18F-fluorodeoxyglucose PET/computed tomography (18F-FDG PET/CT) has demonstrated its utility for the evaluation of gastric cancer; however, considering some histotypes such as gastric signet ring cell carcinoma (GSRCC) the results are limited. The aim of this review is to analyze the diagnostic performance of 18F-FDG PET and PET/CT for the assessment of GSRCC.
A wide literature search of the PubMed/MEDLINE, Scopus, Embase and Cochrane library databases was made to find relevant published articles about the diagnostic performance of 18F-FDG PET or PET/CT for the evaluation of GSRCC.
The comprehensive computer literature search revealed 179 articles. On reviewing the titles and abstracts, 162 articles were excluded because the reported data were not within the field of interest. Nine studies were included in the review and references were also screened for additional articles. Finally, 26 articles were selected and retrieved in full-text version.
Despite some limitations affect our review, GSRCC seems to have low 18F-FDG uptake, and therefore 18F-FDG PET or PET/CT reveals impaired sensitivity for its evaluation. However, a correlation between 18F-FDG uptake and some clinico-pathologic features (such as stage, depth of invasion, size and presence of nodal metastasis) has been demonstrated. Besides, a possible prognostic role of PET/CT features is starting to emerge.
在过去几年中，18F-氟代脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（18F-FDG PET/CT）已证明其在胃癌评估中的效用；然而，考虑到某些组织学类型，如胃印戒细胞癌（GSRCC），结果是有限的。本综述的目的是分析 18F-FDG PET 和 PET/CT 对 GSRCC 的评估的诊断性能。
对 PubMed/MEDLINE、Scopus、Embase 和 Cochrane 图书馆数据库进行广泛的文献检索，以查找有关 18F-FDG PET 或 PET/CT 对 GSRCC 评估的诊断性能的相关已发表文章。
全面的计算机文献检索显示了 179 篇文章。在审查标题和摘要后，排除了 162 篇文章，因为报告的数据不在感兴趣的领域内。有 9 项研究被纳入综述，参考文献也被筛选以获取其他文章。最后，选择并检索了 26 篇全文文章。
尽管存在一些限制影响了我们的综述，但 GSRCC 似乎对 18F-FDG 的摄取较低，因此 18F-FDG PET 或 PET/CT 对其评估的敏感性降低。然而，已经证明 18F-FDG 摄取与一些临床病理特征（如分期、浸润深度、大小和淋巴结转移的存在）之间存在相关性。此外，PET/CT 特征的可能预后作用开始显现。
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