El Baba Hamzah, Hamed Aamer Hassan, Rezvi Syed, Suliman Ahmed, Al-Bahrani Ahmed Z
Department of General Surgery, Hamad Medical Corporation, Doha, QAT.
Department of Upper GI (Gastrointestinal) Surgery, Hamad Medical Corporation, Doha, QAT.
Cureus. 2025 Jun 9;17(6):e85626. doi: 10.7759/cureus.85626. eCollection 2025 Jun.
The association of gastric cancer with parasitic infestation is rather uncommon. We report a case of gastric cancer accompanied by , incidentally found in histopathological examination. While this coexistence may be incidental, the rarity of such a finding prompts consideration of a possible pathophysiological link. A 39-year-old Sudanese man presented with epigastric pain, significant weight loss of 20 kg over six months, and dyspepsia, without nausea or vomiting. His medical history included diabetes mellitus and previous tobacco use. Laboratory investigations revealed anemia, hypoalbuminemia, and elevated tumor markers, including carcinoembryonic antigen (CEA) and cancer antigen 125 (CA 125). Endoscopic evaluation identified a nodular, friable mass with ulceration on the lesser curvature of the stomach, and biopsy confirmed signet-ring cell adenocarcinoma with infestation. Immunohistochemistry revealed HER2 negativity, intact mismatch repair (MMR), and PD-L1 positivity. Computed tomography (CT) imaging demonstrated advanced gastric cancer (cT4cN3M1). Management included palliative chemotherapy, genetic counseling, potential pyloric stenting, and treatment of schistosomiasis. This case illustrates the exceedingly rare histological coexistence of and diffuse-type gastric cancer, underscoring the complex and poorly understood relationship between infectious agents and gastric malignancy. Further research is warranted to elucidate the potential role of in gastric cancer pathogenesis.
胃癌与寄生虫感染的关联相当罕见。我们报告一例胃癌病例，在组织病理学检查中偶然发现伴有[寄生虫名称未给出]。虽然这种共存可能是偶然的，但这一罕见发现促使我们考虑可能的病理生理联系。一名39岁的苏丹男子出现上腹部疼痛，六个月内体重显著减轻20公斤，伴有消化不良，无恶心或呕吐。他的病史包括糖尿病和既往吸烟史。实验室检查显示贫血、低白蛋白血症以及肿瘤标志物升高，包括癌胚抗原（CEA）和癌抗原125（CA 125）。内镜评估发现胃小弯处有一个结节状、易碎且伴有溃疡的肿块，活检证实为印戒细胞腺癌伴[寄生虫名称未给出]感染。免疫组织化学显示HER2阴性、错配修复（MMR）完整以及PD-L1阳性。计算机断层扫描（CT）成像显示为晚期胃癌（cT4cN3M1）。治疗包括姑息化疗、遗传咨询、可能的幽门支架置入以及血吸虫病治疗。该病例说明了[寄生虫名称未给出]与弥漫型胃癌在组织学上极为罕见的共存情况，凸显了感染因子与胃恶性肿瘤之间复杂且尚未完全理解的关系。有必要进行进一步研究以阐明[寄生虫名称未给出]在胃癌发病机制中的潜在作用。
