以[具体内容缺失]为模型检测小分子药物的驱虫活性
Assay to Access Anthelmintic Activity of Small Molecule Drugs Using as a Model.
作者信息
Sant'Anna Viviane, de Souza Wanderley, Vommaro Rossiane C
机构信息
Laboratório de Biologia de Helmintos Otto Wucherer, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Centro de Ciências da Saúde, Cidade Universitária, Bloco G, Ilha do Fundão, Rio de Janeiro, RJ, Brazil.
Laboratório de Ultraestrutura Celular Herta Meyer, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Centro de Ciências da Saúde, Cidade Universitária, Bloco G, Ilha do Fundão, Rio de Janeiro, RJ, Brazil.
出版信息
Bio Protoc. 2017 Jan 20;7(2):e2113. doi: 10.21769/BioProtoc.2113.
This protocol proposes to use the nematode as a model to screen and study the anthelmintic activity of natural and synthetic compounds and to observe their effects on the morphology and the ultrastructure of the helminths. Furthermore, can be used to investigate the anthelmintic activity in embryonated eggs, larval stages and in the adults' survival. As most current anthelmintics are not effective against all nematode life stages, this protocol can contribute to the identification of new alternatives to helminthic infections (Sant' Anna , 2016 ).
本方案建议使用线虫作为模型，以筛选和研究天然及合成化合物的驱虫活性，并观察它们对蠕虫形态和超微结构的影响。此外，该模型可用于研究在带胚卵、幼虫阶段及成虫存活方面的驱虫活性。由于目前大多数驱虫药并非对所有线虫生命周期阶段均有效，因此本方案有助于确定防治蠕虫感染的新替代方法（桑特·安娜，2016年） 。
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