Ogawa Y, Tanaka T, Yamaguchi K, Morozumi M, Kitagawa R
Department of Urology, School of Medicine, Juntendo University.
Hinyokika Kiyo. 1987 Nov;33(11):1772-7.
Male Wistar-strain rats which had been fed a glycolic-acid diet developed severe nephrocalcinosis with urinary calculi within 4 weeks. Rats fed the same diet with citrate salts added had, however, either slight or no nephrocalcinosis without any stones in the urinary system. Nephrocalcinosis intermediate between those in the citrate groups and the glycolic-acid group, with some urinary calculi, was observed in the citric-acid group. During the experiment, the urinary oxalate concentration increased markedly and was higher in the citrate and citric-acid than in the glycolic-acid group. The urinary citrate concentration was significantly higher in the citrate groups and lower in the citric acid and glycolic-acid groups. Therefore, citrate salts can be concluded to inhibit nephrocalcinosis and calculi formation as a result of decreased urinary saturation by means of increase in urinary citrate, in spite of a slight increase in the urinary oxalate.
食用乙醇酸饮食的雄性Wistar品系大鼠在4周内出现了严重的肾钙质沉着症并伴有尿路结石。然而，食用添加柠檬酸盐的相同饮食的大鼠，泌尿系统仅有轻微的肾钙质沉着症或没有肾钙质沉着症，也没有任何结石。在柠檬酸组中观察到肾钙质沉着症程度介于柠檬酸盐组和乙醇酸组之间，且有一些尿路结石。在实验过程中，尿草酸盐浓度显著增加，柠檬酸盐组和柠檬酸组的尿草酸盐浓度高于乙醇酸组。柠檬酸盐组的尿柠檬酸盐浓度显著更高，而柠檬酸组和乙醇酸组的尿柠檬酸盐浓度更低。因此，可以得出结论，尽管尿草酸盐略有增加，但柠檬酸盐可通过增加尿柠檬酸盐来降低尿饱和度，从而抑制肾钙质沉着症和结石形成。
