Ogawa Y, Yamaguchi K, Tanaka T, Morozumi M
Hinyokika Kiyo. 1986 Sep;32(9):1341-7.
Male Wistar-strain rats which had been fed a calcium-oxalate lithogenic diet (a glycolate diet) developed urinary calculi in 4 weeks. Sodium pyruvate or CG-120 (a mixture of citrate salts) had been added to this diet to determine its effect in preventing lithogenicity. Rats in the group fed a pyruvate diet had, however, almost no stones in the urinary system. Rats in the CG-120 group showed results somewhat similar to those in the pyruvate group. Increased urinary citrate excretion was observed in both groups and could be implicated as the main inhibitory factor in stone formation. Therefore, it can be concluded that CG-120 exerts a beneficial effect close to that of pyruvate in preventing calculi formation and that both substances cause a high citrate excretion in urine.
喂食草酸钙致石饮食（乙醇酸饮食）的雄性Wistar品系大鼠在4周内出现了尿路结石。向该饮食中添加丙酮酸钠或CG - 120（柠檬酸盐混合物）以确定其对预防结石形成的作用。然而，喂食丙酮酸盐饮食组的大鼠泌尿系统几乎没有结石。CG - 120组的大鼠结果与丙酮酸盐组的大鼠有些相似。两组均观察到尿柠檬酸盐排泄增加，这可能是结石形成的主要抑制因素。因此，可以得出结论，CG - 120在预防结石形成方面发挥的有益作用与丙酮酸钠相近，且这两种物质都会导致尿液中柠檬酸盐排泄增加。
