Suzuki Kaho, Takaoka Yousuke, Ueda Minoru
Graduate School of Science, Tohoku University 6-3, Aramaki-Aza-Aoba Aoba-ku Sendai 980-8578 Japan
Graduate School of Life Science, Tohoku University 6-3, Aramaki-Aza-Aoba Aoba-ku Sendai 980-8578 Japan.
RSC Chem Biol. 2021 Jan 5;2(2):499-502. doi: 10.1039/d0cb00204f. eCollection 2021 Apr 1.
We herein describe the development of a stapled peptide inhibitor for a jasmonate-related transcription factor. The designed peptide selectively inhibited MYCs, master-regulators of jasmonate signaling, and selectively suppressed MYC-mediated gene expression in . It is proposed as a novel chemical tool for the analysis of MYC related jasmoante signaling.
我们在此描述了一种用于茉莉酸相关转录因子的钉合肽抑制剂的开发。所设计的肽选择性地抑制茉莉酸信号传导的主要调节因子MYCs，并在……中选择性地抑制MYC介导的基因表达。它被提议作为一种用于分析与MYC相关的茉莉酸信号传导的新型化学工具。
