维持性血液透析患者颈动脉内膜中层厚度与左心室质量及左心室质量指数的关系。

Relation between carotid intimal medial thickness and left ventricular mass and left ventricular mass indices in maintenance hemodialysis patients.

机构信息

Department of Internal Medicine, Mansoura Nephrology and Dialysis Unit (MNDU), Mansoura Faculty of Medicine, Mansoura, Egypt.

出版信息

Ther Apher Dial. 2022 Apr;26(2):387-397. doi: 10.1111/1744-9987.13728. Epub 2021 Sep 14.

DOI:10.1111/1744-9987.13728

PMID:34459119

Abstract

Left ventricular hypertrophy (LVH) is a risk factor of cardiovascular morbidity in dialysis patients. The association between LV mass and carotid intimal medial thickness (CIMT) could be due to increased hemodynamic load in dialysis patients. The relationship between CIMT and LVM indices in hemodialysis (HD) patients was investigated. This is a cross-sectional study including 65 HD patients, divided into two groups: Group 1 with CIMT ≤ 1 mm (N = 29), Group 2 with CIMT > 1 mm (N = 36). Echocardiographic evaluation of the LVM, CIMT measurement using B-mode ultrasonography, patients' basic clinical and biochemical data were recorded. Patients with CIMT > 1 mm (Group 2) showed significantly higher LVM, LVM/BSA (body surface area), and LVM/Ht (height). Regarding linear regression, CIMT was found to be an independent predictor for LVM, LVM/BSA, and LVM/Ht . LVM, LVMI, and LVM/Ht are significantly elevated in HD patients with CIMT > 1 mm group. CIMT was found to be the independent predictor for LVH in maintenance HD patients.

摘要

左心室肥厚（LVH）是透析患者心血管发病率的一个危险因素。LV 质量与颈动脉内膜中层厚度（CIMT）之间的关联可能是由于透析患者的血液动力学负荷增加所致。本研究旨在探讨血液透析（HD）患者的 CIMT 与左心室质量指数（LVM）之间的关系。这是一项横断面研究，纳入了 65 名 HD 患者，分为两组：CIMT≤1mm 组（N=29）和 CIMT＞1mm 组（N=36）。对 LVM 进行超声心动图评估，采用 B 型超声测量 CIMT，记录患者的基本临床和生化数据。CIMT＞1mm 组（组 2）的 LVM、LVM/BSA（体表面积）和 LVM/Ht（身高）显著升高。线性回归分析显示，CIMT 是 LVM、LVM/BSA 和 LVM/Ht 的独立预测因子。在 CIMT＞1mm 的 HD 患者中，LVM、LVMI 和 LVM/Ht 显著升高。CIMT 是维持性血液透析患者左心室肥厚的独立预测因子。