Institut Pasteur, Invasive Bacterial Infections Unit and National Reference Centre for Meningococci and Haemophilus Influenzae, Paris, France.
Faculty of Medicine, Université de Paris Sud, Le Kremlin-Bicêtre, France.
Infect Dis (Lond). 2022 Jan;54(1):1-7. doi: 10.1080/23744235.2021.1971289. Epub 2021 Aug 28.
(the meningococcus) causes significant morbidity and mortality worldwide through an epidemic or sporadic invasive infections. The epidemiology of is changing and unpredictable. Certain emerging meningococcal genotypes seem to be associated with increasing unusual clinical presentations. Indeed, early symptoms may vary and are frequently non-specific. However, atypical clinical forms including abdominal presentations, septic arthritis, and bacteremic pneumonia may lead to misdiagnosis and some are usually associated with higher case fatality rates due to delayed optimal management. Improving awareness of clinicians and public health specialists about these unusual but potentially severe presentations should help establish prompt diagnoses and provide appropriate management of cases. In this review, we described unusual panels of clinical presentations of invasive meningococcal disease linked to the recent changes in meningococcal epidemiology.
（脑膜炎球菌）通过流行或散发性侵袭性感染在全球范围内引起重大发病率和死亡率。的流行病学正在发生变化，且难以预测。某些新出现的脑膜炎奈瑟菌基因型似乎与越来越不常见的临床表现有关。事实上，早期症状可能有所不同，且通常不具特异性。然而，包括腹部表现、脓毒性关节炎和菌血症性肺炎在内的非典型临床形式可能导致误诊，且某些形式通常与因延迟进行最佳治疗而导致的更高病死率相关。提高临床医生和公共卫生专家对这些不常见但可能严重的表现的认识，应有助于及时做出诊断并为病例提供适当的治疗。在这篇综述中，我们描述了与脑膜炎奈瑟菌流行病学的近期变化相关的侵袭性脑膜炎球菌病的罕见临床表现。
